ArticleFrontiers in pharmacology2025
Co-delivery of anti-inflammatory and antioxidant agents via polymersomes for osteoarthritis therapy.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Stimuli-Responsive Cell-Mimetic Vesicles for Advanced Pharmaceutical Systems.International journal of nanomedicine · 2026Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Osteoarthritis (OA) is a chronic degenerative joint disease primarily driven by inflammation and oxidative stress. This study aimed to develop a polymersome-based co-delivery system encapsulating hydrophilic cordycepin and hydrophobic phenylboronic acid (PBA) to enhance their solubility, stability, and therapeutic efficacy against OA. Methods: Formulation parameters were optimized using a Taguchi orthogonal design to achieve high encapsulation efficiency, sustained drug release, and effective reactive oxygen species (ROS) scavenging. Results: The optimized co-loaded polymersomes exhibited an average size of 101.03 ± 0.42 nm and a polydispersity index (PDI) of 0.248 ± 0.014. They demonstrated a H Conclusion: This co-delivery system offered a sustained release profile, enhanced joint targeting, and reduced adverse effects, resulting in superior therapeutic outcomes compared to free compounds alone or their combination. These findings highlighted its potential as a promising therapeutic approach for OA management.
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