ReviewFrontiers in pharmacology2025
Unveiling the antioxidant and anti-inflammatory potential of syringic acid: mechanistic insights and pathway interactions.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Syringic acid attenuates chlorpyrifos-induced redox imbalance, mitochondrial depolarization, and apoptosis-related transcriptional changes in HepG2 cells.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Antinociceptive and Anti-Inflammatory Effects of Syringic Acid:ACS omega · 2026Article
- The Nephroprotective Efficacy of Omega-3 Fatty Acids Against Streptozotocin-Induced Diabetic Renal Injury: A Biochemical, Histopathological and Ultrastructural Study.Antioxidants (Basel, Switzerland) · 2026Article
- Effects of syringic acid on the indomethacin-induced gastric ulcer model in rats: in vivo and in silico study.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- New Hybrid Benzothiazole Derivatives from Gallic and Syringic Acid as a Potential Multifunctional Skin Disease.Molecules (Basel, Switzerland) · 2026Article
- Syringic acid pretreatment potentiates antioxidant mechanism and downregulates inflammatory signaling towards doxorubicin-related oxidoinflammatory hepatorenal damage in rats.Scientific reports · 2026Article
- Pharmacokinetics, Excretion, and Metabolite Profiling of Leonurine in Rats: Evidence for Extensive Phase II Conjugations.Molecules (Basel, Switzerland) · 2026Article
- Pressure-dependent supercritical CO₂ extraction of Heliotropium arbainense: phytochemical enrichment and enhanced antimicrobial, anti-inflammatory, and pro-apoptotic activities.Bioresources and bioprocessing · 2026Article
- Beyond Antioxidants: The Microbial Metabolic Landscape of Anthocyanins and Their Downstream Health Implications.Nutrients · 2026Review
- Agro-Industrial Plant Biomass as a Sustainable Source of Anticancer Polyphenols: Molecular Mechanisms and Future Perspectives.Current issues in molecular biology · 2026Review
- In silico and in vitro insights into the wound-healing potential of syringic acid: protective and regenerative effects on human fibroblasts.BMC pharmacology & toxicology · 2026Article
- Syringic acid protects against indomethacin-induced gastric injury via NF-κB and apoptotic pathway modulation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Data-Driven Optimization of Polyphenol Recovery and Antioxidant Capacity from Medicinal Herbs Using Chemometrics and HPLC Profiling for Functional Food Applications.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Syringic acid (SA), a naturally occurring phenolic acid, has garnered significant attention for its antioxidant and anti-inflammatory properties. However, the mechanisms underlying these effects and their potential therapeutic applications require further elucidation. Methods: A comprehensive literature review was conducted using PubMed and Web of Science (1965-2024) to investigate the antioxidant and anti-inflammatory mechanisms of SA, with a focus on oxidative stress and inflammatory pathways. For insights related to traditional Chinese medicine (TCM), we referenced Chinese literature. Articles focusing on agriculture, industry, and economics are excluded. Results: SA exerts potent antioxidant and anti-inflammatory activities through multiple mechanisms. Specifically, it mitigates OS by scavenging free radicals, enhancing endogenous antioxidant defenses, and activating the KEAP1/NRF2 pathway. It also inhibits inflammation by downregulating key mediators, including NF-κB, TLR4, HMGB1, MyD88, and TRAF6. Crosstalk between NRF2, NF-κB, and PI3K/AKT pathways reveals SA's involvement in cellular pathophysiological processes such as apoptosis, ferroptosis, and endoplasmic reticulum stress. Conclusion: SA's robust antioxidant and anti-inflammatory mechanisms underscore its promise as a therapeutic agent. Future research should address its pharmacokinetics, safety profile, and clinical potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.