ArticleAmerican heart journal plus : cardiology research and practice2025
Interplay between subclinical calcified atherosclerosis and coronary microvascular dysfunction in patients with normal perfusion imaging.
Article in American heart journal plus : cardiology research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Immunophenotypes and prognosis in autoimmune cardiovascular disease: a narrative review from clonal hematopoiesis to myocarditis, microvascular angina, and HFpEF.Annals of medicine and surgery (2012) · 2026Review
- Quantification of myocardial blood flow using PET: Current status, clinical applications, and future directions.Progress in cardiovascular diseasesReview
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7 authors.
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Abstract
AimCoronary microvascular dysfunction (CMD) and epicardial atherosclerosis often coexist and share common risk factors, yet their interplay remains poorly characterized, especially among patients with normal perfusion on Methods: A total of 7273 consecutive patients (2010-2020) without known coronary artery disease, normal Results: Mean age was 65.4 (12.4) years, 64 % were women. CMD was present in 44 % and CAC > 0 in 74 % of patients. Of patients with CMD, 79 % had CAC > 0. Among those with CAC >0, 44 % had CMD, vs. 31 % among CAC = 0. There was a modest inverse correlation between MBFR and CACS, Conclusion: In this cohort with normal perfusion imaging, increased CAC burden was associated with a higher likelihood of CMD, suggesting frequent co-occurrence of epicardial atherosclerosis and CMD. Absence of CAC does not preclude CMD.
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