ArticleBioactive materials2025
Mesenchymal stem cell activity across a graded scaffold-hydrogel composite biomaterial for tendon-to-bone enthesis repair.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Hydrogels: current biomedical applications and future directions.Molecular biomedicine · 2026Review
- Multicellular microtissues from fused ligament- and bone-cell spheroids relevant to enthesis repair.Materials today. Bio · 2026Article
- VEGF-sustained regulation and hydrogel-activated graded porous titanium scaffold for functional regeneration of the tendon-bone interface.Materials today. Bio · 2026Article
- From physical modalities to energy-responsive biomaterials: Current strategies and challenges in tendon-to-bone healing.Bioactive materials · 2026Review
- Inclusion of Chondroitin Sulfate Into a Gelatin Hydrogel Shifts Local and Global Mechanical Behavior and Fibrochondrogenic Phenotype for Applications in Insertional Tissue Engineering.Journal of biomedical materials research. Part A · 2026Article
- Advanced engineering strategies for biomaterial scaffolds application in tendon-bone interface regeneration.Burns & trauma · 2026Review
- An interfacial hydrogel compartment within a multicompartment tendon-to-bone scaffold influences cell behavior under cyclic tensile loading.Regenerative biomaterials · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The severity of rotator cuff injury outcomes and a lack of tendon-to-bone enthesis regeneration strategies have inspired advances in biomaterials science to develop methods for interfacial tissue engineering. Here, we demonstrate a triphasic biomaterial comprising a non-mineralized, anisotropic collagen scaffold and a mineralized isotropic collagen scaffold linked via a continuous thiolated gelatin (Gel-SH) interface. This material provides a stratified environment in composition and porous architecture, and we report functional activity of human mesenchymal stem cells (hMSCs) across the scaffold. Notably, MSCs can be seeded onto the triphasic biomaterial and remain viable for up to 21 days. In addition, MSCs within the interfacial Gel-SH interfacial zone express markers associated with the rotator cuff fibrocartilaginous enthesis, including gene upregulation of
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Registered trials
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