Evidence map›Paper›PMID 40703281›Full record

ArticleFrontiers in medicine2025

Adult-onset Still's disease during pregnancy: two case reports and a comprehensive literature review.

Wenchao Xu, Shuang Huang, Juanli Li, Ting Li, Yu Lu, Liu Yang, Jianyu Zhang, Xue Li, Jian Chen

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenchao Xu *Department of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Shuang Huang *Department of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Juanli Li *Department of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Ting LiDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Yu LuDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Liu YangDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Jianyu ZhangDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Xue LiDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Jian ChenDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder marked by recurrent fever, rash, arthritis, and multi-organ involvement. Its occurrence with pregnancy complicates diagnosis and management. Objectives: To present the diagnosis and treatment process of two pregnant patients with newly diagnosed AOSD. Cases: Two cases of AOSD were initially diagnosed during pregnancy. Case one involved a pregnant woman at 16 + 2 weeks of gestation with recurrent fevers, rash, and myalgia. She responded well to treatment with methylprednisolone and cyclosporine and subsequently had a normal vaginal delivery. Case two involved a pregnant woman at 30 + 6 weeks of gestation who presented with systemic joint pain and fever. After being diagnosed with AOSD, she underwent a cesarean section. Treatment included methylprednisolone, cyclosporine, and addition of methotrexate postpartum. Conclusion: Adult-onset Still's disease can be triggered by pregnancy, requiring a multidisciplinary approach for optimal management and fetal outcomes.

Indexed as

Adult-onset Still’s diseaseAOSDinflammatory disorderpregnancy outcomessafe medication use

Identifiers

PMID40703281
PMCPMC12283597

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.