ArticleFrontiers in medicine2025
Early dynamic changes in platelet counts and 28-day mortality in sepsis patients: a retrospective cohort study using dynamic latent class model and generalized additive mixture model analysis.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between neutrophil to lymphocyte ratio and the mortality of patients with sepsis: an update systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- The incremental prognostic value of platelet-to-neutrophil and platelet-to-lymphocyte ratios in patients with sepsis: A retrospective cohort study.The Journal of international medical research · 2026Article
- Platelet Recovery and Mortality in Septic Patients with Thrombocytopenia: A Propensity Score-Matched Analysis of the MIMIC-IV Database.Journal of clinical medicine · 2026Article
- Early peripheral monocyte dynamics are associated with 28-day mortality in acute liver failure: an exploratory longitudinal cohort study.Frontiers in medicine · 2026Article
- Latent trajectory modeling of platelet counts and mortality risk in intensive care unit patients with atrial fibrillation.Science progressArticle
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5 authors.
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Abstract
Objective: This study investigates the relationship between early dynamic changes in platelet (PLT) counts and 28-day mortality in Chinese patients with sepsis, addressing the limitations of previous studies that focused on single baseline measurements. Methods: In this retrospective cohort study, 266 sepsis patients admitted to Shenzhen Second People's Hospital from January 2023 to December 2024 were included. A dynamic latent class model analyzed the patterns of PLT count changes during the first week of hospitalization. The Cox proportional hazards regression model assessed the link between these dynamic changes and 28-day mortality, supported by sensitivity and subgroup analyses for robustness. The GAMM model compared PLT change trajectories over 7 days between the mortality and survival groups. Results: After adjusting for various variables, participants with gradually increasing PLT counts (class 2), decreasing counts (class 3), and persistently low counts (class 4) had hazard ratios (HRs) for 28-day mortality of 1.687 (95% CI:0.380, 7.494), 3.710 (95% CI:1.124, 12.251), and 4.258 (95% CI:1.435, 12.636) respectively, compared to those with persistently high PLT counts (class 1). The GAMM model revealed that PLT counts for patients who died were significantly lower and had a downward trend, while the survival group's counts trended upward; the difference between the two groups generally exhibited an upward trend after admission, with a calculated average daily increase of 12.919 × 10 Conclusion: Early dynamic changes in PLT counts (1-7 days) are independently associated with 28-day mortality in sepsis patients. Those with low and declining PLT counts are at a higher risk. By dynamically monitoring early changes in PLT may help identify high-risk patients and inform personalized treatment strategies, improving outcomes.
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