ArticleFrontiers in medicine2025
Association between triglyceride-glucose index and activities of daily living disability among middle-aged and older patients with arthritis: longitudinal evidence from CHARLS.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the longitudinal association between the triglyceride-glucose (TyG) index and activities of daily living (ADL) disability in middle-aged and older adults with arthritis. Methods: We analyzed data from the China Health and Retirement Longitudinal Study (CHARLS, 2015-2018), including 2,695 arthritis patients without baseline ADL disability. The TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. ADL disability was defined as a score of ≥ 1 based on combined basic and instrumental ADL assessments. Multivariable Cox proportional hazards models were employed to analyze the association, with potential non-linear relationship explored using restricted cubic splines. Results: Over a median follow-up of 35.98 months, 369 participants (13.69%) developed ADL disability. In fully adjusted models, each 1-unit increase in TyG index was associated with a 26% elevated risk of ADL disability (Hazard ratio [HR] = 1.26, 95% confidence interval [CI]: 1.05-1.51). Compared to the Low TyG, the moderate-High TyG and High TyG showed 40% (HR = 1.40, 95%CI: 1.02-1.92) and 64% (HR = 1.64, 95%CI: 1.18-2.29) increased risks, respectively ( Conclusion: Elevated TyG index shows a significant independent association with ADL disability in arthritis patients. These findings provide mechanistic support for the "metabolic-joint axis" hypothesis and suggest that metabolic monitoring might facilitate identification of individuals with elevated risk profiles of functional decline. The TyG index may serve as an economical risk assessment tool in primary care settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.