Evidence map›Paper›PMID 40703193›Full record

ArticleNetwork neuroscience (Cambridge, Mass.)2025

Longitudinal changes in MEG-based brain network topology of ALS patients with cognitive/behavioral impairment-An exploratory study.

Rosanne Govaarts, Elliz P Scheijbeler, Emma Beeldman, Matteo Fraschini, Alessandra Griffa, Marjolein M A Engels, Anneke J van der Kooi, Yolande A L Pijnenburg, Marianne de Visser, Cornelis J Stam and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Network neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rosanne GovaartsAmsterdam UMC location University of Amsterdam, Neurology, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-4550-3977
Elliz P ScheijbelerAmsterdam Neuroscience - Neurodegeneration, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-4582-9563
Emma BeeldmanAmsterdam UMC location University of Amsterdam, Neurology, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0003-0125-4582
Matteo FraschiniUniversity of Cagliari, Electrical and Electronic Engineering, Cagliari, Italy.ORCID https://orcid.org/0000-0003-2784-6527
Alessandra GriffaDepartment of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland.ORCID https://orcid.org/0000-0003-1923-1653
Marjolein M A EngelsAmsterdam UMC location Vrije Universiteit Amsterdam, Clinical Neurophysiology & MEG Center, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0003-1183-058X
Anneke J van der KooiAmsterdam UMC location University of Amsterdam, Neurology, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-5261-5512
Yolande A L PijnenburgAmsterdam Neuroscience - Neurodegeneration, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0003-2464-1905
Marianne de VisserAmsterdam UMC location University of Amsterdam, Neurology, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-5591-7452
Cornelis J StamLeiden University Medical Center, C.J. Gorter MRI Center, Radiology, Leiden, The Netherlands.ORCID https://orcid.org/0000-0001-9163-7274
Joost RaaphorstAmsterdam UMC location University of Amsterdam, Neurology, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-3658-2001
Arjan HillebrandAmsterdam UMC location Vrije Universiteit Amsterdam, Clinical Neurophysiology & MEG Center, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-8508-3532

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) with only motor impairment (ALS-pure motor) and the behavioral variant of frontotemporal dementia (bvFTD) are hypothesized to represent extreme ends of a disease spectrum, which encompasses ALS with cognitive/behavioral impairment (ALSci/bi). In this longitudinal magnetoencephalography (MEG) study, we investigated changes in brain network topology of ALSci/bi over time as compared with ALS-pure motor and bvFTD patients. Resting-state MEG was recorded in ALS-pure motor (

Indexed as

Amyotrophic lateral sclerosisBehavioral variant frontotemporal dementiaFunctional network topologyMagnetoencephalographyMinimum spanning treeResting-state

Identifiers

PMID40703193
PMCPMC12283152

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.