ArticleNetwork neuroscience (Cambridge, Mass.)2025
Joint estimation of source dynamics and interactions from MEG data.
Article in Network neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Current techniques to estimate directed functional connectivity from magnetoencephalography (MEG) signals involve two sequential steps: (a) estimation of the sources and their amplitude time series from the MEG data and (b) estimation of directed interactions between the source time series. However, such a sequential approach is not optimal as it leads to spurious connectivity due to spatial leakage. Here, we present an algorithm to jointly estimate the source and connectivity parameters using Bayesian filtering. We refer to this new algorithm as JEDI-MEG (Joint Estimation of source Dynamics and Interactions from MEG data). By formulating a state-space model for the locations and amplitudes of a given number of sources, we show that estimation of their connections can be reduced to a system identification problem. Using simulated MEG data, we show that the joint approach provides a more accurate reconstruction of connectivity parameters than the conventional two-step approach. Using real MEG responses to visually presented faces in 16 subjects, we also demonstrate that our method gives source and connectivity estimates that are both physiologically plausible and largely consistent across subjects. In conclusion, the proposed joint estimation approach outperforms the traditional two-step approach in determining functional connectivity in MEG data.
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