ArticleRSC advances2025
Selective heterofunctionalization of kynurenic acid derivatives.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
The latest findings in the literature show that kynurenic acid and its analogues are potent drug candidates against numerous neurological diseases. In this article, kynurenic acid derivatives were treated with NaOCl and NaOBr solutions and yielded the corresponding 3-halogeno compounds. The reaction is fast and conducted under mild conditions, and the yields are efficient just like the previous methods available for the same transformation. These newly synthesized halogeno compounds can serve as starting materials for the synthesis of 3-aminokynurenic acid analogues by treating the 3-bromokynurenic acid analogue with NaN
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