ArticleRSC advances2025
Fluorescent imaging of glutathione distribution in frozen tissue slices based on TLC tracing technology.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
The distribution of glutathione (GSH) in liver tissue is an important indicator for disease assessment. GSH depletion increases the susceptibility to oxidative stress and is involved in many diseases. Although mass spectrometry imaging (MSI) is a powerful tool for analysing the distribution of metabolites, it is difficult to image the distribution of reactive metabolites, such as the GSH bearing thiol group. In addition, MSI needs high-end instruments and takes a long time. In this study, we aimed to construct a methodology to trace GSH in frozen tissue slices onto a thin layer chromatography (TLC) plate by labelling with a fluorescent dye
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Registered trials
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