Evidence map›Paper›PMID 40702921›Full record

ArticleJournal of medicinal chemistry2025

SAR-Guided Development of Small-Molecule SERCA2a Activators: Discovery of Potent Indoline, Benzofuran, and Benzodioxole Analogs for Cardiovascular Applications.

Adam Ard, Carlos Cruz-Cortés, Xinmin Gan, Guadalupe Guerrero-Serna, Andrew D White, Martin C Clasby, L Michel Espinoza-Fonseca

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Development of activators for SERCA2a for heart failure treatments.European journal of medicinal chemistry · 2026
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Adam ArdDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
Carlos Cruz-CortésDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
Xinmin GanDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
Guadalupe Guerrero-SernaFrankel Cardiovascular Center, Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
Andrew D WhiteDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-7869-0118
Martin C ClasbyDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-7852-1733
L Michel Espinoza-FonsecaDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0009-0007-1006-6504

Funding

Interdepartmental Training in Pharmacological SciencesT32GM140223 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lori L. Isom · 2021 to 2026
$3.8M
Hit-to-lead optimization for heart failure drug discoveryR01HL148068 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ESPINOZA-FONSECA, LENNANE MICHEL, HERRON, TODD JOSEPH · 2019 to 2022
$2.9M
Mechanisms and discovery of small-molecule effectors targeting cardiac ion pumpsR01HL176212 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lennane Michel Espinoza-Fonseca · 2024 to 2026
$1.7M
NHLBI NIH HHS R01 HL148068NHLBI NIH HHS R01 HL176212NIGMS NIH HHS T32 GM140223
6 · The paper itself

Abstract

Heart failure (HF) remains a major public health burden, with current therapies focused primarily on symptom management. Impaired activity of the cardiac Ca

Indexed as

BenzofuransIndolesSarcoplasmic Reticulum Calcium-Transporting ATPasesSmall Molecule LibrariesAnimalsCalciumDrug DiscoveryHumansMolecular StructureStructure-Activity RelationshipbenzofuranBenzofuransCalciumIndolesindolineSarcoplasmic Reticulum Calcium-Transporting ATPasesSmall Molecule Libraries

Identifiers

PMID40702921
PMCPMC12336636

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.