ArticleBritish journal of clinical pharmacology2025
Medication persistence trajectories among individuals prescribed lipid-lowering therapy in primary care settings: A retrospective cohort study.
Article in British journal of clinical pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Medication persistence trajectories among individuals prescribed lipid-lowering therapy in primary care settings: A retrospective cohort study.British journal of clinical pharmacology · 2025Article
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13 authors.
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Abstract
aimsThis study aimed to identify distinct trajectories of lipid-modifying medication (LMM) persistence over time and to explore characteristics associated with each pattern.
methodsUsing primary care data from IQVIA, we conducted a retrospective cohort study of adults prescribed LMMs between January 2015 and December 2017, with 5 years of follow-up. Persistence was defined as ≥1 prescription every 6 months. Group-based trajectory modelling identified medication persistence patterns; characteristics were compared using 1-way ANOVA and chi-squared tests.
resultsAmong 51 504 individuals (mean age 62 years, 53% male), 4 distinct trajectories were identified: persistent use (PU, 20%), gradual decline (10%), rapid decline (29%) and early discontinuation (41%). Compared to those who discontinued early, individuals in the rapid decline, gradual decline and PU groups were older by 1.18 (95% confidence interval: 0.82-1.55), 2.61 (2.08-3.13) and 3.71 (3.30-4.12) years, respectively. Persistent users were more likely to have cardiovascular risk factors: a higher proportion of smokers (44.4 vs. 39.6%), elevated systolic blood pressure (≥140 mmHg: 36.9 vs. 32.9%) and reduced renal function (estimated glomerular filtration rate >45 mL/min/m
conclusionsDistinct profiles across trajectories highlight the need for tailored interventions to improve long-term medication use, particularly among younger, healthier individuals and those residing in metropolitan areas.
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