Evidence map›Paper›PMID 40702880›Full record

Observational studyEuropean journal of heart failure2025

Artificial intelligence fully automated analysis of handheld echocardiography in real-world patients with suspected heart failure.

Ross T Campbell, Mark C Petrie, Kieran F Docherty, Katriona J M Brooksbank, Gemma McKinley, Caroline Haig, Alex McConnachie, Carolyn S P Lam, Carly Adamson, Elaine Butler and 23 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in European journal of heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Diagnostic Tests for Stage B Heart Failure.Current cardiology reports · 2026
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Ross T CampbellSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.ORCID https://orcid.org/0000-0002-0050-2129
Mark C PetrieSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Kieran F DochertySchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.ORCID https://orcid.org/0000-0002-5446-9969
Katriona J M BrooksbankSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Gemma McKinleyRobertson Centre for Biostatistics, School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Caroline HaigRobertson Centre for Biostatistics, School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Alex McConnachieRobertson Centre for Biostatistics, School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Carolyn S P LamNational Heart Centre Singapore and Duke-National University of Singapore, Singapore, Singapore.
Carly AdamsonSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Elaine ButlerSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
James P CurtainSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Nick Hartshorne-EvansPumping Marvellous, Preston, UK.
Fraser J GrahamCardiology Department, Queen Elizabeth University Hospital, Glasgow, UK.
Helen HaineyCardiology Department, Queen Elizabeth University Hospital, Glasgow, UK.
John JarvieSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Matthew M Y LeeSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.ORCID https://orcid.org/0000-0001-9213-2067
Leeanne MacklinCardiology Department, Forth Valley Royal Hospital, Larbert, UK.
Kenneth MangionCardiology Department, Queen Elizabeth University Hospital, Glasgow, UK.ORCID https://orcid.org/0000-0002-3505-7440
Aimee McCoubreySchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Kirsty McDowellSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Aileen McIntyreResearch and Innovation department, NHS Greater Glasgow and Clyde, Glasgow, UK.
Sabrina NordinCardiology Department, Queen Elizabeth University Hospital, Glasgow, UK.
Joanna OsmanskaSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Pierpaolo PellicoriSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Joanne SimpsonCardiology Department, Queen Elizabeth University Hospital, Glasgow, UK.
Piotr SoneckiCardiology Department, Queen Elizabeth University Hospital, Glasgow, UK.
Karen TaylorCardiology Department, Queen Elizabeth University Hospital, Glasgow, UK.
Daniel Taylor-SweetSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Pamela TurnbullCardiology Department, Glasgow Royal Infirmary, Glasgow, UK.
Paul WelshSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
John J V McMurraySchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.ORCID https://orcid.org/0000-0002-6317-3975
Clare L MurphyCardiology Department, Forth Valley Royal Hospital, Larbert, UK.
David J LoweSchool of Health and Wellbeing, University of Glasgow, Glasgow, UK.ORCID https://orcid.org/0000-0003-4866-2049

Funding

AstraZenecaBritish Heart Foundation RE/18/6/34217Roche Diagnostics
6 · The paper itself

Abstract

aimsEchocardiography is a rate-limiting step in the timely diagnosis of heart failure (HF). Automated reporting of echocardiograms has the potential to streamline workflow. The aim of this study was to test the diagnostic accuracy of fully automated artificial intelligence (AI) analysis of images acquired using handheld echocardiography and its interchangeability with expert human-analysed cart-based echocardiograms in a real-world cohort with suspected HF. METHODS AND

resultsIn this multicentre, prospective, observational study, patients with suspected HF had two echocardiograms: one handheld portable and one cart-based scan. Both echocardiograms were analysed using fully automated AI software and by human expert sonographers. The primary endpoint was the diagnostic accuracy of AI-automated analysis of handheld echocardiography to detect left ventricular ejection fraction (LVEF) ≤40%. Other endpoints included the interchangeability (assessed using individual equivalence coefficient [IEC]), between AI-automated and human analysis of cart-based LVEF. A total of 867 patients participated. The AI-automated analysis produced an LVEF in 61% of the handheld scans and 77% of the cart-based scans, compared to 76% and 77% of human analyses of the handheld and cart-based scans, respectively. The AI-automated analysis of handheld echocardiography had a diagnostic accuracy of 0.93 (95% confidence interval [CI] 0.90, 0.95) for identifying LVEF ≤40% (compared to the human analysis of cart-based transthoracic echocardiography scans). AI-automated analysis of LVEF on handheld devices was interchangeable with cart-based LVEF reported by two expert humans (IEC -0.40, 95% CI -0.60, -0.16).

conclusionsArtificial intelligence-automated analysis of handheld echocardiography had good diagnostic accuracy for detecting LVEF ≤40%. AI-automated analysis of LVEF of handheld scans was interchangeable with cart-based expert human analysis.

Indexed as

Artificial IntelligenceEchocardiographyHeart FailureStroke VolumeVentricular Function, LeftAgedFemaleHumansMaleMiddle AgedProspective StudiesArtificial intelligenceDiagnosisEchocardiographyHandheldHeart failurePoint of care

Identifiers

PMID40702880
PMCPMC12803686

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.