Evidence map›Paper›PMID 40702822›Full record

ArticleGut microbes2025

Microbial genetic composition regulates host social behavior.

Ruijie Bai, Tao Wang, Rongrong Gu, Yawei Cai, Juntao Chen, Wen Cai, Dianshuang Zhou, Ying Li, Jixun Luo, Xiangming Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ruijie BaiJiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China.
Tao WangJiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China.
Rongrong GuJiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China.
Yawei CaiThe First Clinical College, Xuzhou Medical University, Xuzhou, China.
Juntao ChenThe First Clinical College, Xuzhou Medical University, Xuzhou, China.
Wen CaiJiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China.
Dianshuang ZhouJiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China.
Ying LiMedical Technology College, Xuzhou Medical University, Xuzhou, China.
Jixun LuoSchool of Life Sciences, Huzhou University, Huzhou, Zhejiang, China.
Xiangming WangDepartment of Cell Biology, School of Basic Medical Sciences, Laboratory for Clinical Medicine, Capital Medical University, Beijing, China.
Zuobin ZhuJiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The co-evolutionary relationship between gut microbiota and their hosts is influenced by microbial genetic variation, which enables adaptation to host environmental changes, modifies metabolic processes, and refines host-microbiota interactions. Investigating how gut microbial genetic variations influence host neurobehavior can provide insights into the pathogenesis of neurological disorders. In this study, we screened a comprehensive single-gene knockout library of

Indexed as

Caenorhabditis elegansEscherichia coliGastrointestinal MicrobiomeHost Microbial InteractionsSocial BehaviorAnimalsBehavior, AnimalCaenorhabditis elegans ProteinsGene Knockout TechniquesMutationSignal TransductionTransforming Growth Factor betaTyrosineCaenorhabditis elegans ProteinsTransforming Growth Factor betaTyrosineCaenorhabditis elegansgenetic variationgut microbiotasocial behaviortyrosine metabolism

Identifiers

PMID40702822
PMCPMC12309553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.