Evidence map›Paper›PMID 40702821›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Associations between blood-based neurodegenerative biomarkers and cognitive functioning and decline in India.

Emma Nichols, Jinkook Lee, Alden L Gross, Masroor Anwar, Abhishek Gupta, Eileen M Crimmins, Bharat Thyagarajan, Sharmistha Dey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emma NicholsCenter for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-9005-3872
Jinkook LeeCenter for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
Alden L GrossJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Masroor AnwarDepartment of Biophysics, All India Institute of Medical Sciences, New Delhi, Delhi, India.
Abhishek GuptaDepartment of Biophysics, All India Institute of Medical Sciences, New Delhi, Delhi, India.
Eileen M CrimminsLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Sharmistha DeyDepartment of Biophysics, All India Institute of Medical Sciences, New Delhi, Delhi, India.ORCID 0000-0003-4122-7415

Funding

Leveraging a natural experiment to estimate the causal impact of blood sugar on dementia and cognition in IndiaR01AG051125 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jinkook Lee · 2015 to 2026
$26.8M
USC/UCLA Center on Biodemography &Population HealthP30AG017265 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE · 1999 to 2026
$17.9M
Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Study of India (LASI)-Genomic study.U01AG064948 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KARDIA, SHARON L, LEE, JINKOOK · 2019 to 2023
$12.5M
Biomarkers of neurodegeneration in the US and India: A cross-national evaluation of the biological underpinnings of ADRDRF1AG088003 · NIA · JOHNS HOPKINS UNIVERSITY · PI CRIMMINS, EILEEN M, GROSS, ALDEN L. · 2024 to 2024
$2.4M
NIA NIH HHS P30 AG017265NIA NIH HHS R01 AG051125NIA NIH HHS RF1 AG088003NIA NIH HHS U01 AG064948
6 · The paper itself

Abstract

BackgroundMounting evidence supports the use of blood-based neurodegenerative biomarkers as a low-cost, minimally invasive tool for studying Alzheimer's disease and other dementias, but existing data largely come from clinical samples or high-income settings. Despite emphasis in the literature on the importance of understanding the utility of neurodegenerative biomarkers in diverse populations, published analyses are limited.ObjectiveTo assess the utility of neurodegenerative biomarkers in India by quantifying associations between biomarkers and cognitive outcomes in a nationally representative cohort study.MethodsWe quantified associations between five neurodegenerative blood biomarkers (amyloid-β 42/40 (Aβ

Indexed as

CognitionCognitive DysfunctionAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersCohort StudiesCross-Sectional StudiesFemaleGlial Fibrillary Acidic ProteinHumansIndiaLongitudinal StudiesMaleMiddle AgedNeurofilament ProteinsAmyloid beta-PeptidesBiomarkersGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament ProteinsPeptide Fragmentstau ProteinsAlzheimer's diseaseamyloidblood-based biomarkerscognitioncognitive declinedementiaglial fibrillary acidic proteinneurodegenerationneurofilament lighttau

Identifiers

PMID40702821
PMCPMC12507122

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.