Evidence map›Paper›PMID 40702689›Full record

ArticleJournal of applied research in intellectual disabilities : JARID2025

The Use of the Anxiety, Depression and Mood Scale (ADAMS) as a Screening Instrument for Depression and Mental Health Diagnoses in a Down Syndrome Specialty Clinic.

Mary Witt, Anna J Esbensen, Ayesha Harisinghani, Nicolas M Oreskovic, Michelle Palumbo, Stephanie L Santoro

Abstract read
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Article in Journal of applied research in intellectual disabilities : JARID, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Mary WittDivision of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.
Anna J EsbensenDivision of Developmental and Behavioral Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0003-2649-7791
Ayesha HarisinghaniDivision of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.
Nicolas M OreskovicDivision of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-8702-8636
Michelle PalumboDivision of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.
Stephanie L SantoroDivision of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-4172-0288

Funding

Developing a Down Syndrome Health InstrumentK23HD100568 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI SANTORO, STEPHANIE LYNN · 2020 to 2024
$847k
Eunice Kennedy Shriver National Institute on Child Health and Human Development of the National Institutes of Health K23HD100568NICHD NIH HHS K23 HD100568
6 · The paper itself

Abstract

introductionThe Anxiety, Depression and Mood Scale (ADAMS), a mental health screening tool developed for individuals with intellectual disabilities, has yet to be evaluated in adults with Down syndrome. We included the ADAMS in a Dementia Protocol.

methodWe reviewed the charts of 71 adults with Down syndrome seen in a specialty clinic and collected ADAMS data from our quality improvement project. We evaluated the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the ADAMS at five cutoff points to identify optimal screening thresholds for adults with Down syndrome.

resultsCutoff points set at two points below the 75th percentile scores of the original ADAMS publication presented optimal sensitivity of 81.82%, specificity of 82.93%, PPV of 72.00% and NPV of 89.47%.

conclusionFor adults with Down syndrome, we suggest alternate thresholds, generally two points below the original ADAMS thresholds, to adequately capture mental health concerns.

Indexed as

AnxietyDepressionDown SyndromePsychiatric Status Rating ScalesAdultAgedFemaleHumansMaleMiddle AgedSensitivity and SpecificityYoung Adultadultsdementiadown syndromemental healthpsychiatricpsychologyscreening instrumentstrisomy 21

Identifiers

PMID40702689
PMCPMC13284729

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.