Evidence map›Paper›PMID 40702598›Full record

ReviewTransplantation2026

Cryopreservation Strategies to Improve Access to Organ Transplantation.

Alissa M Cutrone, O Sila Ozgur, Arnaud Lyon, Alban Longchamp, Joren C Madsen, Heidi Yeh, Korkut Uygun

Abstract readReview
In one paragraph

Review in Transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alissa M CutroneCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA.
O Sila OzgurCenter for Engineering in Medicine and Surgery, Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA.
Arnaud LyonCenter for Engineering in Medicine and Surgery, Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA.
Alban LongchampCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA.
Joren C MadsenCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA.
Heidi YehCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA.
Korkut UygunCenter for Engineering in Medicine and Surgery, Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA.

Funding

High subzero preservation of liver for transplantationR01DK114506 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI TONER, MEHMET, UYGUN, KORKUT · 2017 to 2025
$4.4M
Metabolic Modeling for Cadaveric Organ ResuscitationR01DK096075 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI UYGUN, KORKUT, YEH, HEIDI · 2012 to 2022
$3.9M
Normothermic perfusion of steatotic livers for transplantationR01DK131543 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Heidi Yeh · 2024 to 2026
$777k
NIDDK NIH HHS R01 DK096075NIDDK NIH HHS R01 DK114506NIDDK NIH HHS R01 DK131543
6 · The paper itself

Abstract

Organ transplantation is the only definitive cure for end-stage organ failure. The primary obstacle is the scarcity of viable donor organs, resulting in many patients dying on the transplant waitlist. The last decade has brought a range of transformative technologies to address this shortage: machine perfusion has risen as an option to greatly increase the human donor organ utilization, while xenotransplantation further promises to fundamentally alter the calculus in supply constraints. Given this increasing availability, the logistics of allocation rises as the next key technological barrier. Cryopreservation strategies aim to increase the viable storage time for organs and thereby enable the creation of a cold-supply chain for clinical transplantation. This technology has the potential to overcome limitations related to preservation and transportation, histocompatibility matching, complex organ allocation and wastage, and in tandem with xenotransplantation, provide an unlimited off-the-shelf supply of organs. This review aims to cover the latest research updates in the use of cryopreservation, how it compares to current clinical preservation strategies, and discuss how its implementation into the world of transplantation may require new logistical, ethical and regulatory frameworks.

Indexed as

CryopreservationHealth Services AccessibilityOrgan PreservationOrgan TransplantationTissue and Organ ProcurementTissue DonorsAnimalsHumansTransplantation, Heterologous

Identifiers

PMID40702598
PMCPMC13359655

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.