Evidence map›Paper›PMID 40702579›Full record

ReviewJournal of health, population, and nutrition2025

Comprehensive narrative analysis of antimicrobial resistance in Afghanistan: key drivers, challenges, and strategic interventions.

Hedayatullah Ehsan, Fazel Rahim Wardak, Hasiba Karimi, Fariha Kamal, Hasibullah Aminpoor, Abdul Salam, Hira Tariq, Rameen Damani, Mohamed Nasser Elshabrawi, Mehak Faisal and 7 more

Abstract readReview
In one paragraph

Review in Journal of health, population, and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hedayatullah EhsanFaculty of Medicine and Dentistry, Medical Sciences Research Center, Ghalib University, Kabul, Afghanistan. hedayatullahehsan@gmail.com.ORCID 0000-0001-5970-713X
Fazel Rahim WardakDepartment of Internal Medicine, Kabul University of Medical Sciences "Abu Ali Ibn Sina", Kabul, Afghanistan.
Hasiba KarimiCanHealth International, Vancouver, BC, Canada.
Fariha KamalDepartment of Oral Medicine, Kabul University of Medical Sciences "Abu Ali Ibn Sina", Kabul, Afghanistan.
Hasibullah AminpoorFaculty of Medicine, Kabul University of Medical Sciences "Abu Ali Ibn Sina", Kabul, Afghanistan.
Abdul SalamDepartment of Medical Imaging Technology, Gandhara University, Peshawar, Pakistan.
Hira TariqUniversity of Punjab, Lahore, Pakistan.
Rameen DamaniDow University of Health Sciences, Karachi, Pakistan.
Mohamed Nasser ElshabrawiDepartment of Pediatrics, University of Port Said, Port Fouad, Egypt.
Mehak FaisalDepartment of Medicine, Karachi Medical and Dental College, Karachi, Pakistan.
Chukwuagoziem Augustine IloanusiFaculty of Clinical Sciences, University of Uyo, Akwa Ibom, Nigeria.
Ayushmaan RoyFaculty of Pharmacy, Kalinga University Raipur, Raipur, Chattisgarh, India.
Izza ShakeelDepartment of Medicine, Allama Iqbal Medical College, Lahore, Pakistan.
Sharvari JoshiDepartment of Medicine, Kasturba Medical College, Manipal, India.
Md AbubakarDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Vaishali, India.
Abubakr YosufiMedical School, Kabul University of Medical Sciences "Abu Ali Ibn Sina", Kabul, Afghanistan.
Ahmad Jamshid MehrpoorFaculty of Medicine and Dentistry, Medical Sciences Research Center, Ghalib University, Kabul, Afghanistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntimicrobial resistance (AMR) presents a global health crisis, and Afghanistan, with its limited healthcare infrastructure, faces an acute AMR challenge. Factors such as overuse of antibiotics, unregulated drug sales, and low public awareness contribute to an accelerated spread of resistant pathogens. This study offers a comprehensive narrative analysis of the drivers of AMR in Afghanistan and proposes strategic, context-specific interventions.

methodsA narrative review was conducted using available literature and national reports to assess AMR prevalence in Afghanistan, identify contributing socio-political and healthcare challenges, and evaluate the impact of these challenges on AMR surveillance and control.

findingsHigh resistance rates are prevalent among key pathogens, including Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae, with resistance to first-line antibiotics exceeding 80% for many infections. Afghanistan's fragile healthcare infrastructure, compounded by unregulated antibiotic sales and self-medication practices, exacerbates AMR rates. Limited AMR surveillance and inadequate infection control practices further intensify the crisis.

interpretationAddressing AMR in Afghanistan requires urgent, coordinated action. Recommendations include strengthening healthcare infrastructure, enforcing antibiotic regulations, enhancing surveillance, and implementing public education campaigns. Worldwide teamwork is vital to building a resilient healthcare system to address Afghanistan's unique AMR challenges effectively. These interventions are crucial to controlling the spread of AMR and preventing a healthcare crisis.

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialAfghanistanHumansKlebsiella pneumoniaePrevalenceAnti-Bacterial AgentsAfghanistanAntibiotic misuseAntimicrobial resistance (AMR)Global cooperationHealthcare infrastructureInfection preventionPublic healthSurveillanceUnregulated pharmaceutical market

Identifiers

PMID40702579
PMCPMC12285168

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.