Evidence map›Paper›PMID 40702517›Full record

ArticleInternational journal of retina and vitreous2025

Genotype-specific retinal and choroidal perfusion patterns in inherited retinal diseases: an SS-OCTA analysis.

Yu Rong, Junfeng Li, Jianquan He, Daowei Zhang, Jiawen Wu, Hongli Liu, Ting Li, Ping Xu, Qing Chang, Jihong Wu

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of retina and vitreous, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yu Rong *Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.
Junfeng Li *Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.
Jianquan HeDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.
Daowei ZhangDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.
Jiawen WuDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.
Hongli LiuDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.
Ting LiDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.
Ping XuDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.
Qing ChangDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China. qngchang@aliyun.com.
Jihong WuDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China. Jihongwu@fudan.edu.cn.

Funding

NSFC 82271085, 82171055Program of Shanghai Municipal Commission of Science and Technology 21S11905900the National Key Research and Develpment Program of China 2020YFA0112700, 2020YFA0112703Xuhui Hospital and regional cooperation project 23XHYD-28
6 · The paper itself

Abstract

backgroundRetinitis pigmentosa (RP), an inherited retinal disease, is characterized by progressive vision loss driven by the gradual degeneration of retinal photoreceptors. This process manifests as impaired dark adaptation, night blindness, constriction of the visual field, and the deterioration of central vision. Although the progression can be monitored by electroretinography (ERG), visual field (VF) tests and optical coherence tomography (OCT) to some extent, it's hard to achieve high repeatability. Considering the correlation between patients' retinal blood volume and their visual function, OCT angiography (OCTA) can be a good choice for monitoring RP progression by objectively quantifying vascular changes.

methodsThis study included 62 patients and 21 matched controls. Patients with RP were classified into five groups based on their genotype (CYP4V2, EYS, PRPH2, RPGR, and USH2A). Quantitative measurements and analyses were performed in nine fields of the fundus.

resultsDefects were observed in each layer among all RP groups, showing different patterns of damage to the vasculature of the SCP, DCP, CC, and MLC. Foveal avascular zone (FAZ) sizes of the SCP and DCP in CYP4V2 and EYS groups, respectively, were larger than those in healthy individuals; PDs were associated with retinal function in each group. The CVI decreased to various degrees based on genotype and was associated with retinal function.

conclusionPatients with RP had decreased PDs in the retina and choroid. PDs correlated with specific genotypes and retinal functions. SS-OCTA may be a non-invasive method for detecting the severity of RP.

Indexed as

Choroidal vascularity indexFoveal avascular zoneGenotypeInherited retinal diseasesPerfusion densityRetinitis pigmentosaSS-OCTA

Identifiers

PMID40702517
PMCPMC12288356

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