ArticleVirology journal2025
Profiles and kinetics of PgRNA and clinical characteristics in pregnant, postpartum, and non-pregnant women with chronic HBV infection.
Article in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Predictive value and mechanism of LINC00665 for liver dysfunction in pregnant women with hepatitis B during early pregnancy.Virology journal · 2026Article
- Higher risk of postpartum phase transition to immune-active among HBeAg-positive pregnant women with indeterminate phase.Frontiers in cellular and infection microbiology · 2025Observational
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9 authors.
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Abstract
backgroundPregenomic RNA (pgRNA) has been utilized as an early predictive marker for antiviral therapy, an indicator for the emergence of drug resistance in hepatitis B virus (HBV), or a marker for safe discontinuation of nucleoside analog therapy. However, its role during pregnancy has rarely been reported. We aimed to evaluate the pgRNA profiles and its dynamic changes among pregnant, postpartum, and non-pregnant women with chronic HBV infection (CHB).
methodsWe conducted a study involving 479 women with CHB, including 235 during pregnancy, 90 postpartum, and 154 non-pregnant women of childbearing age. pgRNA was detected using the HBV-SAT method. Additionally, we followed up 39 women in mid-pregnancy, 21 in late pregnancy, 20 within 0-3 months postpartum, and 20 non-pregnant women of childbearing age with different treatment regimens for two times.
resultsSignificant differences were observed in clinical indicators such as HBV DNA, ALT, AST, and pgRNA among CHB women during pregnancy, postpartum, and non-pregnant periods. Pregnant and postpartum women with positive pgRNA had higher levels of DNA, HBeAg, HBsAg, and ALT. Moreover, the detection rates of pgRNA, DNA, and HBeAg varied significantly across the three stages and different treatment regimens in CHB women. pgRNA was highly correlated with HBeAg, and a moderate correlation was found between pgRNA and HBV DNA levels. This study also revealed the patterns of viral activity changes during pregnancy and postpartum, and the first three months postpartum represent a critical period for viral activity changes. This unique immune adjustment phase may offer new opportunities for the treatment of hepatitis B.
conclusionCHB women have different pgRNA and clinical characteristics during pregnancy, postpartum, and the non-pregnant childbearing period.
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