Pediatric peripapillary choroidal neovascularization secondary to ocular sarcoidosis: a long-term follow-up case.

Yuan Zong, Keyan Wang, Ting Zhang, Gezhi Xu

Abstract readCase Reports

In one paragraph

Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

4 authors.

Yuan ZongEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.

Keyan WangEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.

Ting ZhangEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China. tina-chang07@163.com.

Gezhi XuEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.

Funding

National Natural Science Foundation of China 82201204Shanghai Hospital Development Center Foundation SHDC12023116

6 · The paper itself

Abstract

backgroundTo describe a 14-year-old male with probable ocular sarcoidosis and bilateral peripapillary choroidal neovascularization (PCNV). CASE PRESENTATION: We report a case of a 14-year-old boy with a 2-month history of floaters and gradual vision loss in both eyes. Examination revealed bilateral granulomatous uveitis with peripapillary subretinal lesions. The serum angiotensin-converting enzyme was elevated. Positron emission tomography demonstrated increased metabolic activity in the nasopharynx and small intestine, consistent with diagnosis of sarcoidosis. Despite resolution of vitreous cells and retinal vasculitis, the PCNV progressed slowly in the left eye, which was controlled with combined treatment of immunomodulatory regiment and multiple intravitreal anti-vascular endothelial growth factor injections over a prolonged period.

conclusionsThis case highlights the need for a multidisciplinary approach and long-term follow-up in pediatric ocular sarcoidosis with PCNV.

Indexed as

Choroidal NeovascularizationSarcoidosisAdolescentAngiogenesis InhibitorsFluorescein AngiographyFollow-Up StudiesHumansMaleTomography, Optical CoherenceAngiogenesis InhibitorsAnti-vascular endothelial growth factorChoroidal neovascularizationImmunosuppressive agentsPediatricSarcoidosisUveitis

Identifiers

PMID40702433

DOI10.1186/s12886-025-04266-7

PMCPMC12285086

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.