ArticleAging clinical and experimental research2025
Bone status in patients with chronic hypoparathyroidism: results from the Italian HypoparaNET database.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Clinical Characteristics, Treatment Patterns, and Complications in Permanent Hypoparathyroidism: A Large Retrospective Cross-Sectional Study.Calcified tissue international · 2026Article
- Clinical profile, treatment practices, and complications in chronic hypoparathyroidism in a Middle Eastern cohort.Journal of the Endocrine Society · 2026Article
- Successful transition from rhPTH(1-84) to palopegteriparatide in chronic hypoparathyroidism.JCEM case reports · 2026Article
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20 authors.
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Abstract
backgroundChronic hypoparathyroidism (HypoPT) is a rare endocrine condition, having variable etiology, characterized by low parathyroid hormone levels, leading to reduced calcium levels and increased phosphorus values in the blood. Bone health is an important clinical aspect to be considered in patients with HypoPT, whose skeleton is exposed both to the HypoPT-induced alteration of bone mass and microarchitecture, and to the natural occurrence and progression of bone mass loss due to menopause and ageing.
aimInvestigating bone status in a cohort of Italian HypoPT patients from the HypoparaNET database.
methodsIn this cross-sectional study, we retrospectively analyzed bone status in 162 adult, and 11 children and adolescent HypoPT cases, based to their sex, age, HypoPT etiology, urinary excretion of calcium and phosphate, and serum level of 25(OH)-vitamin D.
resultsOverall prevalence of osteoporosis in adult HypoPT patients was found to be slightly lower to that of the general population (17.3% vs 18.3%), increasing with ageing and being more frequent in postmenopausal women. Data from our HypoPT cohort confirmed that ageing and female sex are independent risk factors for osteoporosis, even among individuals with HypoPT. DISCUSSION: Results from this study suggest the importance of a regular follow-up of bone health in HypoPT, especially in postmenopausal women and young patients with a genetic form of HypoPT.
conclusionsMedical therapies aim at restoring a balanced bone turnover and preventing bone tissue loss could be indicated in HypoPT cases with reduced bone mass to grant a better bone health at any age.
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