Evidence map›Paper›PMID 40702360›Full record

ReviewCommunications biology2025

Adipose-derived mesenchymal stromal/stem cells in type 1 diabetes treatment.

Vanshika Sood, Hannah Ricioli, George Chigozie Njoku, Rosita Primavera, Susana Dietrich, Avnesh S Thakor, Flemming Pociot, Reza Yarani

Abstract readReview
In one paragraph

Review in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vanshika SoodTranslational Type 1 Diabetes Research, Department of Clinical and Translational Research, Steno Diabetes Center Copenhagen, Herlev, Denmark.
Hannah RicioliTranslational Type 1 Diabetes Research, Department of Clinical and Translational Research, Steno Diabetes Center Copenhagen, Herlev, Denmark.
George Chigozie NjokuTranslational Type 1 Diabetes Research, Department of Clinical and Translational Research, Steno Diabetes Center Copenhagen, Herlev, Denmark.ORCID http://orcid.org/0000-0003-1369-6396
Rosita PrimaveraInterventional Radiology Innovation at Stanford (IRIS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA.
Susana DietrichDepartment of Science & Health, DIS Study Abroad in Scandinavia, Copenhagen, Denmark.
Avnesh S ThakorInterventional Radiology Innovation at Stanford (IRIS), Department of Radiology, School of Medicine, Stanford University, Stanford, CA, USA.
Flemming PociotTranslational Type 1 Diabetes Research, Department of Clinical and Translational Research, Steno Diabetes Center Copenhagen, Herlev, Denmark.
Reza YaraniTranslational Type 1 Diabetes Research, Department of Clinical and Translational Research, Steno Diabetes Center Copenhagen, Herlev, Denmark. reza.yarani.01@regionh.dk.ORCID http://orcid.org/0000-0002-9892-1937

Funding

Lundbeckfonden (Lundbeck Foundation) R303-2018-3148
6 · The paper itself

Abstract

Adipose tissue-derived mesenchymal stromal/stem cells (ADMSCs) represent a novel therapeutic intervention for Type 1 Diabetes (T1D). The attractiveness of ADMSCs is characterized by their immunomodulatory activities, regenerative properties, and relative ease of access. ADMSC therapies in animal models and clinical trials have revealed decreased insulin dependence, increased β cell mass, and improved islet graft acceptance. Despite their potential, challenges in quality control, small-scale investigations, functional heterogeneity, and standardization limit the application of these therapies. This review synthesizes the current knowledge and recent outcomes of ADMSC therapies in treating T1D and highlights areas that need further investigation.

Indexed as

Adipose TissueDiabetes Mellitus, Type 1Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationAnimalsHumans

Identifiers

PMID40702360
PMCPMC12287536

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.