ArticleNature neuroscience2025
Noradrenergic activation of the basolateral amygdala facilitates memory specificity for similar events experienced close in time.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Post-encoding administration of oxytocin selectively enhances memory consolidation of male faces in females.Proceedings of the National Academy of Sciences of the United States of America · 2026Trial
- Noradrenaline causes a spread of association in the hippocampal cognitive map.Nature communications · 2026Article
- Emotional learning selectively distorts the temporal organization of memory: A quantitative synthesis.Cognition · 2026Article
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Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Noradrenergic activation of the basolateral amygdala (BLA) promotes strong and lasting memories of emotionally arousing experiences. However, in our lives, we often encounter similar events that may be confused and result in emotional strengthening of incorrect associations. Here we provide evidence, in rats, that noradrenergic activation of the BLA promotes the formation of discrete memories of similar events that were experienced close in time, via a miR-134-regulated consolidation process within the dentate gyrus of the hippocampus. Targeted downregulation of miR-134 in the hippocampus was sufficient to induce memory specificity, without affecting the strength of the memory. Notably, noradrenergic activation of the BLA did not recruit this hippocampal miR-134-mediated mechanism in enhancing memory of a single event. These findings indicate that the BLA engages a qualitatively different neural mechanism on an 'as-needed' basis to facilitate the separation of similar memory representations, enabling the selective strengthening of correct associations into long-term memory.
Indexed as
Identifiers
40702323What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.