Evidence map›Paper›PMID 40702319›Full record

ArticleBiotechnology letters2025

Recombinant protein CP01850 adjuvanted with Iridea cordata or Sacorpletis skottibergii lipid extracts protected mice against infection by Corynebacterium pseudotuberculosis.

Tallyson Nogueira Barbosa, Nicole Ramos Scholl, Mara Thais de Oliveira Silva, Adriane Leites Strothmann, Henrique Gonçalves Pegoraro, Fernanda Severo Sabedra Sousa, Fabiana Kommling Seixas, Francisco Silvestre Brilhante Bezerra, Tiago Veiras Collares, Cláudio Martin Pereira de Pereira and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Biotechnology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tallyson Nogueira BarbosaLaboratório de Biotecnologia Infecto-Parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, Universidade Federal de Pelotas (UFPel), Campus Universitário S/N, Prédio 19, Pelotas, RS, 96010-900, Brazil.
Nicole Ramos SchollLaboratório de Biotecnologia Infecto-Parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, Universidade Federal de Pelotas (UFPel), Campus Universitário S/N, Prédio 19, Pelotas, RS, 96010-900, Brazil.
Mara Thais de Oliveira SilvaLaboratório de Biotecnologia Infecto-Parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, Universidade Federal de Pelotas (UFPel), Campus Universitário S/N, Prédio 19, Pelotas, RS, 96010-900, Brazil.
Adriane Leites StrothmannLaboratório de Biotecnologia Infecto-Parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, Universidade Federal de Pelotas (UFPel), Campus Universitário S/N, Prédio 19, Pelotas, RS, 96010-900, Brazil.
Henrique Gonçalves PegoraroLaboratório de Biotecnologia Infecto-Parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, Universidade Federal de Pelotas (UFPel), Campus Universitário S/N, Prédio 19, Pelotas, RS, 96010-900, Brazil.
Fernanda Severo Sabedra SousaLaboratório de Biotecnologia do Câncer, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS, 96010-900, Brazil.
Fabiana Kommling SeixasLaboratório de Biotecnologia do Câncer, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS, 96010-900, Brazil.
Francisco Silvestre Brilhante BezerraLaboratório de Vacinologia e Imunologia Aplicada, Centro de Ciências Biológicas e da Saúde, UFERSA, Mossoró, RN, 59625-900, Brazil.
Tiago Veiras CollaresLaboratório de Biotecnologia do Câncer, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS, 96010-900, Brazil.
Cláudio Martin Pereira de PereiraLaboratório de Lipidômica e Bio-Orgânica, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, UFPel, Pelotas, RS, 96010-900, Brazil.
Andrés MansillaCape Horn International Center (CHIC), Universidad de Magallanes, Punta Arenas, Chile.
Sibele BorsukLaboratório de Biotecnologia Infecto-Parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, Universidade Federal de Pelotas (UFPel), Campus Universitário S/N, Prédio 19, Pelotas, RS, 96010-900, Brazil. sibeleborsuk@gmail.com.ORCID http://orcid.org/0000-0003-1774-0059

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, new immunomodulatory compounds have benn sought as effective adjuvants in vaccine development. In this context, the bioactive substances from macroalgae stand out, as they can satisfactorily activate an immune response against infectious diseases, such as caseous lymphadenitis (CLA), caused by Corynebacterium pseudotuberculosis. This study aimed to evaluate the adjuvant activity of Iridea cordata and Sacorpletis skotibergii lipid extracts associated with the protein rCP01850 against infection by C. pseudotuberculosis in a murine model. Five groups of ten BALB/c mice each were inoculated with 0.9% saline (G1), rCP01850 (G2), rCP01850 + saponin (G3), rCP01850 + Iridea cordata (G4), and rCP01850 + Sacorpletis skotibergii (G5). Two doses of vaccine were administered with a 21-day interval between doses. After that, the animals were challenged with 2 × 10

Indexed as

Adjuvants, ImmunologicCorynebacterium InfectionsCorynebacterium pseudotuberculosisLipidsAnimalsBacterial VaccinesCytokinesDisease Models, AnimalFemaleMiceMice, Inbred BALB CRecombinant ProteinsAdjuvants, ImmunologicBacterial VaccinesCytokinesLipidsRecombinant ProteinsBioactive compoundsImmunoprophylaxisNatural productsRecombinant antigensVaccine testing

Identifiers

PMID40702319

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.