New amino-naphthoic acid derivatives produced by biological transformation using the deep-sea-derived bacterium Serinicoccus marinus KDM482.

Mai Sakaguchi, Katsuki Kikuchi, Ryota Okamura, Akito Taniguchi, Kenichiro Nagai, Reiko Seki, Masashi Ando, Teruyoshi Tanaka, Takashi Fukuda

Abstract read

PubMed Publisher

In one paragraph

Article in The Journal of antibiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mai SakaguchiDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.

Katsuki KikuchiDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.

Ryota OkamuraDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.

Akito TaniguchiDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.

Kenichiro NagaiMedicinal Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.

Reiko SekiMedicinal Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.

Masashi AndoDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.

Teruyoshi TanakaDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan.

Takashi FukudaDepartment of Fisheries, Faculty of Agriculture, Kindai University, Nara, Japan. fukudata@nara.kindai.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep-sea-derived microorganisms are quite attractive as resources for new secondary metabolites, enzymes, and gene discovery. We have isolated many marine microorganisms from deep-sea creatures and screened the new secondary metabolites produced by them. Two new molecules designated amino-naphthoic acid derivatives (1 and 2) were obtained by biological transformation using the deep-sea derived bacterium Serinicoccus marinus KDM482 successfully. Structural analysis using 1D and 2D NMR and MS data revealed that both 1 and 2 were dimerized compounds of 3-amino-2-naphthoic acid. In biological assays, 1 and 2 moderately inhibited the growth of Malme-3M cells.

Indexed as

MicrococcaceaeNaphthalenesAntineoplastic AgentsBiotransformationHeterocyclic Compounds, 3-RingHumansMagnetic Resonance SpectroscopyMolecular StructureAntineoplastic AgentsHeterocyclic Compounds, 3-RingNaphthalenes

Identifiers

PMID40702305

DOI10.1038/s41429-025-00845-4

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.