Evidence map›Paper›PMID 40702261›Full record

ReviewNature2025

Integrated biotechnological and AI innovations for crop improvement.

Guotian Li, Linna An, Wanneng Yang, Lei Yang, Tong Wei, Jiawei Shi, Jianglin Wang, John H Doonan, Kabin Xie, Alisdair R Fernie and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Artificial intelligence-driven advancements in agricultural biotechnology.Journal, genetic engineering & biotechnology · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. From Defense Executor to Engineering Target: Harnessing Lignin for Crop Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  10. Review
  11. Harnessing artificial intelligence in plant breeding: innovations in digital phenotyping and breeding methodologies.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Guotian Li *National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Hubei Key Laboratory of Plant Pathology, The Center of Crop Nanobiotechnology, Huazhong Agricultural University, Wuhan, China. li4@mail.hzau.edu.cn.ORCID 0000-0001-6780-7085
Linna An *Department of Biochemistry, Institute for Protein Design, The University of Washington, Seattle, WA, USA.
Wanneng Yang *National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0003-1095-1355
Lei Yang *National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Hubei Key Laboratory of Plant Pathology, The Center of Crop Nanobiotechnology, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0002-8615-0311
Tong WeiBGI Research, Wuhan, China.ORCID 0000-0002-2692-7192
Jiawei ShiNational Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, China.
Jianglin WangNational Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, China.
John H DoonanThe National Plant Phenomics Centre, Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, UK.
Kabin XieNational Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0003-0643-2456
Alisdair R FernieMax Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.ORCID 0000-0001-9000-335X
Evans S LagudahCommonwealth Scientific and Industrial Research Organisation, Agriculture and Food, Canberra, Australian Capital Territory, Australia.ORCID 0000-0002-6234-1789
Rod A WingBiological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.ORCID 0000-0001-6633-6226
Caixia GaoNew Cornerstone Science Laboratory, Center for Genome Editing, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. cxgao@genetics.ac.cn.ORCID 0000-0003-3169-8248

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crops provide food, clothing and other important products for the global population. To meet the demands of a growing population, substantial improvements are required in crop yield, quality and production sustainability. However, these goals are constrained by various environmental factors and limited genetic resources. Overcoming these limitations requires a paradigm shift in crop improvement by fully leveraging natural genetic diversity alongside biotechnological approaches such as genome editing and the heterologous expression of designed proteins, coupled with multimodal data integration. In this Review, we provide an in-depth analysis of integrated uses of omics technologies, genome editing, protein design and high-throughput phenotyping, in crop improvement, supported by artificial intelligence-enabled tools. We discuss the emerging applications and current challenges of these technologies in crop improvement. Finally, we present a perspective on how elite alleles generated through these technologies can be incorporated into the genomes of existing and de novo domesticated crops, aided by a proposed artificial intelligence model. We suggest that integrating these technologies with agricultural practices will lead to a new revolution in crop improvement, contributing to global food security in a sustainable manner.

Indexed as

Artificial IntelligenceBiotechnologyCrops, AgriculturalAgricultureAllelesCrop ProductionFood SecurityGene EditingPhenotypePlant BreedingPlants, Genetically Modified

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.