Evidence map›Paper›PMID 40702234›Full record

ArticleScientific reports2025

Novel purine-linked 1,2,3-triazole derivatives as effective anticancer agents: design, synthesis, docking, DFT, and ADME-T investigations.

Khaja Mohiddin Shaik, Komala Pandurangan, Tejeswara Rao Allaka, Seshadri Nalla, Srinivas Ganta, Mohammad Z Ahmed, Srinivasadesikan Venkatesan, Pilli Veera Venkata Nanda Kishore

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Khaja Mohiddin ShaikDepartment of Chemistry, School of Applied Sciences, REVA University, Bengaluru, 560064, Karnataka, India.
Komala PanduranganDepartment of Chemistry, School of Applied Sciences, REVA University, Bengaluru, 560064, Karnataka, India. komala.pandurangan@reva.edu.in.
Tejeswara Rao AllakaCentre for Chemical Sciences and Technology, University College of Engineering Science and Technology Hyderabad, Jawaharlal Nehru Technological University Hyderabad, Hyderabad, 500085, Telangana, India. tejajntuh18@gmail.com.
Seshadri NallaLamar University, 4400 S M L King Jr Pkwy, Beaumont, TX, 77705, USA.
Srinivas GantaScieGen Pharmaceutical Inc Hauppauge, New York, 11788, USA.
Mohammad Z AhmedDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.
Srinivasadesikan VenkatesanDepartment of Chemistry, School of Applied Sciences and Humanities, Vignan's Foundation for Science, Technology and Research, Vadlamudi, Guntur, 522213, Andhra Pradesh, India.
Pilli Veera Venkata Nanda KishoreDepartment of Chemistry, School of Applied Sciences and Humanities, Vignan's Foundation for Science, Technology and Research, Vadlamudi, Guntur, 522213, Andhra Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The elaboration of a new family of purine molecules bearing triazole-acetamide units is presented. The structure assigned to such molecules was verified by various techniques, including FT-IR, NMR (

Indexed as

Antineoplastic AgentsPurinesTriazolesA549 CellsCell Line, TumorCell SurvivalDensity Functional TheoryDrug DesignDrug Screening Assays, AntitumorHCT116 CellsHeLa CellsHumansMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentspurinePurinesTriazoles1,23-triazoleADME-TAnti-proliferative activityDFTDocking interactionsPurine

Identifiers

PMID40702234
PMCPMC12287522

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.