Evidence map›Paper›PMID 40702215›Full record

ArticleScientific reports2025

Loss of TRPV4 is insufficient to promote repair in a spinal cord injury contusion model.

Melanie Mertens, Sofie Kessels, Naomi Veeningen, Elle E M Scheijen, Femke Mussen, Amber Delbroek, Jana Van Broeckhoven, Yeranddy A Alpizar, Bert Brône

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Melanie MertensDepartment of Neuroscience, Biomedical research institute, Hasselt University, 3500, Hasselt, Belgium.
Sofie KesselsDepartment of Neuroscience, Biomedical research institute, Hasselt University, 3500, Hasselt, Belgium.
Naomi VeeningenDepartment of Immunology and Infection, Biomedical research institute, Hasselt University, 3500, Hasselt, Belgium.
Elle E M ScheijenDepartment of Neuroscience, Biomedical research institute, Hasselt University, 3500, Hasselt, Belgium.
Femke MussenDepartment of Neuroscience, Biomedical research institute, Hasselt University, 3500, Hasselt, Belgium.
Amber DelbroekDepartment of Neuroscience, Biomedical research institute, Hasselt University, 3500, Hasselt, Belgium.
Jana Van BroeckhovenDepartment of Immunology and Infection, Biomedical research institute, Hasselt University, 3500, Hasselt, Belgium.
Yeranddy A Alpizar *Laboratory of Molecular Vaccinology & Vaccine Discovery (MVVD), Department of Microbiology, Immunology & Transplantation, Rega Institute, 3000, Leuven, Belgium. yeranddy.aguiaralpizar@kuleuven.be.
Bert Brône *Department of Neuroscience, Biomedical research institute, Hasselt University, 3500, Hasselt, Belgium. bert.brone@uhasselt.be.

Funding

bijzonder onderzoeksfonds UHasselt Belgium 21DOC21BOFBijzonder onderzoeksfonds UHasselt Belgium 21KP06BOF
6 · The paper itself

Abstract

Microglia, the primary phagocytes activated after spinal cord injury (SCI), play a key role in containing the lesion and protecting the glial scar from infiltrating immune cells. Although these responses are initially protective, excessive microglial proliferation and sustained pro-inflammatory activation can worsen secondary damage and limit recovery. Modulating microglial activity has been proposed as a potential therapeutic approach to enhance SCI repair. Previous studies suggest that constitutive loss of the mechanosensory channel TRPV4 (transient receptor potential vanilloid 4) reduces microgliosis and inflammation at the lesion site, improving functional outcomes. TRPV4 is a Ca

Indexed as

ContusionsSpinal Cord InjuriesTRPV Cation ChannelsAnimalsDisease Models, AnimalFemaleMiceMice, KnockoutMicrogliaPhagocytesRecovery of FunctionTrpv4 protein, mouseTRPV Cation ChannelsBone marrow transplantationContusion modelPhagocytesSpinal cord injuryTransient receptor potential vanilloid 4

Identifiers

PMID40702215
PMCPMC12287530

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.