Evidence map›Paper›PMID 40702179›Full record

ArticleNature2025

Driving a protective allele of the mosquito FREP1 gene to combat malaria.

Zhiqian Li, Yuemei Dong, Lang You, Rodrigo M Corder, Jemariz Arzobal, Audrey Yeun, Lei Yang, John M Marshall, George Dimopoulos, Ethan Bier

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhiqian Li *Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Yuemei Dong *Department of Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-7902-2899
Lang YouDepartment of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Rodrigo M CorderDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-8929-2200
Jemariz ArzobalDepartment of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Audrey YeunDepartment of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.
Lei YangDepartment of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-0549-7258
John M MarshallDivisions of Biostatistics and Epidemiology, School of Public Health, University of California, Berkeley, CA, USA.ORCID 0000-0003-0603-7341
George DimopoulosDepartment of Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA. gdimopo1@jhu.edu.ORCID 0000-0001-6755-8111
Ethan BierDepartment of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA. ebier@ucsd.edu.ORCID 0000-0002-2892-3005

Funding

Mosquito SAMSP1 and SAMSP2 influence the initial stage of Plasmodium infection of miceR01AI158615 · NIAID · YALE UNIVERSITY · PI DIMOPOULOS, GEORGE, FIKRIG, EROL · 2021 to 2025
$4.1M
Impact of gene-drive systems for population modification on malaria vector mosquitoesR01AI170692 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI DIMOPOULOS, GEORGE, JAMES, ANTHONY A. · 2023 to 2025
$3.2M
The mutagenic chain reaction: a method for autocatalyic gene disseminationR01GM117321 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BIER, ETHAN · 2016 to 2024
$2.5M
Development of next-generation gene drive technologies for Anopheles population engineeringR01AI162911 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BIER, ETHAN · 2021 to 2025
$2.3M
Understanding mosquito movement and its relevance to control through genetic analysisR01AI143698 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI MARSHALL, JOHN MACKY · 2020 to 2024
$1.7M
Analysis of homolog-based CRISPR editing in somatic cellsR01GM144608 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BIER, ETHAN · 2022 to 2025
$1.3M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
Gates Foundation INV-017683Gates Foundation INV-036579Gates Foundation INV-043645NIAID NIH HHS R01 AI143698NIAID NIH HHS R01 AI158615NIAID NIH HHS R01 AI162911NIAID NIH HHS R01 AI170692NIGMS NIH HHS R01 GM117321NIGMS NIH HHS R01 GM144608NIH HHS S10 OD026929
6 · The paper itself

Abstract

Malaria remains a substantial global health challenge, causing approximately half a million deaths each year

Indexed as

AnophelesFibrinogenGene Drive TechnologyGenes, InsectMosquito VectorsAllelesAnimalsFemaleGenetic FitnessHumansInsect ProteinsMalariaMaleMiceFibrinogenInsect Proteins

Identifiers

PMID40702179
PMCPMC12443604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.