Evidence map›Paper›PMID 40702172›Full record

ArticleNature2025

Humoral determinants of checkpoint immunotherapy.

Yile Dai, Lilach Aizenbud, Kai Qin, Matthew Austin, Jillian R Jaycox, Joseph Cunningham, Eric Y Wang, Lin Zhang, Suzanne Fischer, Sean M Carroll and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Humoral contributions to checkpoint blockade therapy.Journal for immunotherapy of cancer · 2026
    Article
  8. Article
  9. Article
  10. The Five-Decade Journey of Small Cell Lung Cancer.Cancer communications (London, England) · 2026
    Review
  11. Article
  12. Explore antibody repertoire in the era of AI.Acta biochimica et biophysica Sinica · 2025
    Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yile Dai *Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7761-3361
Lilach Aizenbud *Yale Cancer Center, New Haven, CT, USA.
Kai Qin *Division of Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Matthew AustinYale Cancer Center, New Haven, CT, USA.
Jillian R JaycoxDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Joseph CunninghamProgram of Applied Mathematics, Yale University, New Haven, CT, USA.
Eric Y WangDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Lin ZhangYale Cancer Center, New Haven, CT, USA.
Suzanne FischerDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Sean M CarrollSeranova Bio, South San Francisco, CA, USA.
Helen van AggelenSeranova Bio, South San Francisco, CA, USA.
Yuval KlugerProgram of Applied Mathematics, Yale University, New Haven, CT, USA.ORCID 0000-0002-3035-071X
Kevan C HeroldDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-1534-6613
Leon FurchtgottSeranova Bio, South San Francisco, CA, USA. leon@seranovabio.com.ORCID 0000-0002-4258-0950
Harriet M KlugerYale Cancer Center, New Haven, CT, USA. harriet.kluger@yale.edu.ORCID 0000-0002-4932-9873
Aaron M RingDivision of Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA, USA. aaronring@fredhutch.org.ORCID 0000-0003-3699-2446

Funding

Mark Foundation for Cancer Research and the Pew Charitable TrustsYale Medical Scientist Training Program
6 · The paper itself

Abstract

Although the role of cellular immunity in checkpoint immunotherapy (CPI) for cancer is well established

Indexed as

AutoantibodiesImmune Checkpoint InhibitorsImmunity, HumoralImmunotherapyNeoplasmsAnimalsCohort StudiesFemaleHumansInterferon Type IMaleMiceMiddle AgedAutoantibodiesImmune Checkpoint InhibitorsInterferon Type I

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.