Evidence map›Paper›PMID 40702171›Full record

ReviewNature biomedical engineering2025

Harnessing electroencephalography connectomes for cognitive and clinical neuroscience.

Yu Zhang, Zhe Sage Chen

Abstract readReview
In one paragraph

Review in Nature biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  4. Review
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yu ZhangWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA. yzhangsu@stanford.edu.ORCID http://orcid.org/0000-0003-4087-6544
Zhe Sage ChenDepartment of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA. zhe.chen@nyulangone.org.ORCID http://orcid.org/0000-0002-6483-6056

Funding

Thalamocortical cognitive networks in the healthy human brainP50MH132642 · NIMH · PRINCETON UNIVERSITY · PI SABINE KASTNER · 2023 to 2026
$15.7M
Machine learning approaches for improving EEG data utility in SUDEP researchR01NS123928 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DEVINSKY, ORRIN, FRIEDMAN, DANIEL · 2021 to 2025
$3.1M
Establishing Multimodal Brain Biomarkers Using Data-driven Analyticsfor Treatment Selection in DepressionR01MH129694 · NIMH · STANFORD UNIVERSITY · PI Yu Zhang · 2023 to 2026
$2.8M
Cortical information integration as a model for pain perception and behaviorRF1NS121776 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHEN, ZHE SAGE, WANG, JING · 2021 to 2021
$2.0M
CRNS: An Integrative Study of Hippocampal-Neocortical Memory Coding during Sleep R01MH118928 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHEN, ZHE SAGE, WILSON, MATTHEW A · 2018 to 2022
$1.8M
CRCNS: Dissection and control of cognitive thalamocortical dynamicsR01MH139352 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Zhe Sage Chen, Michael M Halassa · 2024 to 2026
$1.4M
Predictive Biosignature for Endoscopic Therapy for Chronic Pancreatitis PainUG3NS135170 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHEN, ZHE SAGE, DOAN, LISA · 2023 to 2023
$1.2M
Cortical Information Integration as a Model for Pain Perception and BehaviorR01NS121776 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHEN, ZHE SAGE, WANG, JING · 2024 to 2025
$1.2M
Dissection of spatiotemporal activity from large-scale, multi-modal, multi-resolution hippocampal-neocortical recordings.RF1DA056394 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BUZSAKI, GYORGY, CHEN, ZHE SAGE · 2022 to 2022
$1.1M
Assess Neural Circuits and Subtypes Underlying Dimensions of Neuropsychiatric Symptoms in Alzheimer's DiseaseR21AG080425 · NIA · LEHIGH UNIVERSITY · PI ZHANG, YU · 2023 to 2024
$426k
Identifying Transdiagnostic Functional Connectivity Biomarkers for Cognitive Health and PsychopathologyR21MH130956 · NIMH · LEHIGH UNIVERSITY · PI BERDICHEVSKY, YEVGENY · 2023 to 2024
$409k
NIA NIH HHS R21 AG080425NIDA NIH HHS RF1 DA056394NIMH NIH HHS P50 MH132642NIMH NIH HHS R01 MH118928NIMH NIH HHS R01 MH129694NIMH NIH HHS R01 MH139352NIMH NIH HHS R21 MH130956NINDS NIH HHS R01 NS121776NINDS NIH HHS R01 NS123928NINDS NIH HHS RF1 NS121776NINDS NIH HHS UG3 NS135170U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 118928U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 123928U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 129694U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 132642U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 121776U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 123928U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 135170U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) 080425U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) 056394
6 · The paper itself

Abstract

Electroencephalography (EEG) connectomes offer powerful tools for studying brain connectivity and advancing our understanding of brain function and dysfunction in both healthy and pathological conditions. Celebrating the 100th anniversary of EEG discovery, this Perspective explores the frontiers of EEG-based brain connectivity in basic and translational neuroscience research. We review new concepts, emerging analysis frameworks and significant advances in harnessing EEG connectomes. We suggest that leveraging machine learning approaches may offer promising paths to maximize the strengths of EEG connectomes. We also discuss how combined EEG connectome and neuromodulation provide a personalized and adaptive closed-loop paradigm to promote neuroplasticity and treat dysfunctional brains. We further address the limitations and challenges of the current methodology and touch on important issues regarding research rigour and clinical viability for translational impact.

Indexed as

BrainCognitionConnectomeElectroencephalographyNeurosciencesAnimalsHumansMachine LearningNeuronal Plasticity

Identifiers

PMID40702171
PMCPMC12360501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.