ArticleScientific reports2025
Early gestation heat stress influences fetal biomarkers indicative of maternal cortisol transfer in pigs.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Effects of Supplementing Yeast Culture to Prepartum Cows Under Heat Stress on the Jejunal Microbiota and Metabolites of Calves.Animals : an open access journal from MDPI · 2026Article
- Reproductive efficiency and longevity of gilts and sows in group housing and free-farrowing systems versus traditional crate systems in tropical environments.BMC veterinary research · 2026Article
- Characterizing the effects of gestational heat stress on reproductive efficiency and thermoregulation in replacement gilts divergently selected for thermotolerance in the F1 generation.Journal of animal science · 2025Article
- Prenatal stress and neuroendocrine pathways framing attention-deficit/hyperactivity disorder as a functionally based neurodevelopmental disorder: a narrative review.Journal of Yeungnam medical science · 2025Article
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Authors and funding
5 authors.
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Abstract
In utero heat stress (IUHS) alters hypothalamic-pituitary-adrenal (HPA) axis development in pigs; however, the mechanisms mediating this effect remain unclear. This study aimed to evaluate cortisol transfer dynamics from the heat-stressed (HS) dam to the IUHS conceptus during early gestation. We hypothesized that gestational HS would modify maternal cortisol secretion and increase conceptus cortisol exposure. Twenty-three gilts were exposed to thermoneutral (TN; n = 11) or HS (n = 12) conditions from gestation d 6 to 33. Maternal vaginal temperature, respiration rate, skin temperatures, and salivary cortisol concentrations were monitored. On d 33, dams were harvested to assess fetal and reproductive tract morphology and collect fetal and placental samples for glucocorticoid and 11β-HSD2 analyses. Heat-stressed gilts exhibited increased (P ≤ 0.01) vaginal temperature, respiration rate, and skin temperatures, but salivary cortisol was similar (P = 0.13). Total and viable fetuses per corpus luteum were reduced (P ≤ 0.05) in HS dams. Fetal tissue cortisone: cortisol tended to be reduced (P = 0.06) and was reduced in IUHS fetus amniotic fluid (P = 0.03). Amniotic fluid cortisone tended to decrease (P = 0.07), while cortisol tended to increase (P = 0.08) in IUHS fetuses. These data suggest IUHS increases fetal glucocorticoid exposure.
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