Evidence map›Paper›PMID 40702123›Full record

ArticleScientific reports2025

Automated descriptive cell type naming in flow and mass cytometry with CytoPheno.

Amanda R Tursi, Celine S Lages, Kenneth Quayle, Zachary T Koenig, Rashi Loni, Shruti Eswar, José Cobeña-Reyes, Sherry Thornton, Tamara Tilburgs, Sandra Andorf

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Amanda R TursiDepartment of Biomedical Informatics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Celine S LagesDivision of Rheumatology, Research Flow Cytometry Facility, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Kenneth QuayleDivision of Rheumatology, Research Flow Cytometry Facility, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Zachary T KoenigDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Rashi LoniDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Shruti EswarDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
José Cobeña-ReyesDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Sherry ThorntonDivision of Rheumatology, Research Flow Cytometry Facility, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Tamara TilburgsDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Sandra AndorfDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. andorfsa@ucmail.uc.edu.

Funding

Tissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan · 2016 to 2026
$7.7M
ZE5 Analytical CytometerS10OD025045 · OD · CINCINNATI CHILDRENS HOSP MED CTR · PI THORNTON, SHERRY L · 2018 to 2018
$359k
Burroughs Wellcome Fund Next Gen Pregnancy Award #NGP10115Cincinnati Children's Research Foundation Trustee AwardNIAMS NIH HHS P30 AR070549NIH HHS P30AR070549NIH HHS S10 OD025045
6 · The paper itself

Abstract

Advances in cytometry have led to increases in the number of cellular markers that are routinely measured. The resulting complexity of the data has prompted a shift from manual to automated analysis methods. Currently, numerous unsupervised methods are available to cluster cells based on marker expression values. However, phenotyping the resulting clusters is typically not part of the automated process. Manually identifying both marker definitions (e.g. CD4

Indexed as

Flow CytometryAlgorithmsBiomarkersCD4-Positive T-LymphocytesCluster AnalysisHumansImmunophenotypingSoftwareBiomarkers

Identifiers

PMID40702123
PMCPMC12287297

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.