Evidence map›Paper›PMID 40702030›Full record

ArticleScientific reports2025

Enhancing the regulatory function of the autonomic nervous system using sounds with inaudible high-frequency components.

Koto Jogasaki, Norie Kawai, Emi Nishina, Manabu Honda

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Koto JogasakiDepartment of Information Medicine, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan.
Norie KawaiDepartment of Information Medicine, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan.
Emi NishinaDepartment of Liberal Arts, The Open University of Japan, 2-11 Wakaba, Mihama, Chiba, 261-8586, Japan.
Manabu HondaDepartment of Information Medicine, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan. honda@ncnp.go.jp.

Funding

JSPS KAKENHI 19H01093JSPS KAKENHI 23K11370JST Moonshot R&D JPMJMS2296
6 · The paper itself

Abstract

The dysregulation of the autonomic nervous system (ANS) activity notably contributes to the onset and progression of numerous diseases, including lifestyle-related and psychiatric disorders. This necessitates the development of effective nonpharmacological methods for regulating ANS function for therapeutic purposes and disease prevention. This study examined how the presence or absence of the inaudible high-frequency component (HFC) of sounds-which activates deep-brain structures-affects the ANS regulatory function. Under the N-back task condition, which requires concentration, exposure to sounds with HFC resulted in significantly higher sympathetic and parasympathetic nervous activities compared to sounds without HFC. Conversely, under the relaxation condition, the sounds with HFC significantly suppressed sympathetic nervous activity relative to sounds without HFC. Therefore, sounds with HFC may flexibly adjust the sympathetic and parasympathetic nervous activities based on situational demands.

Indexed as

Autonomic Nervous SystemSoundAcoustic StimulationAdultFemaleHeart RateHumansMaleParasympathetic Nervous SystemSympathetic Nervous SystemYoung AdultAutonomic nervous systemHomeostasisHypersonic effectInaudible high-frequency sounds

Identifiers

PMID40702030
PMCPMC12287281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.