Evidence map›Paper›PMID 40702007›Full record

ArticleNature communications2025

Large-vocabulary forensic pathological analyses via prototypical cross-modal contrastive learning.

Chen Shen, Chunfeng Lian, Wanqing Zhang, Fan Wang, Jianhua Zhang, Shuanliang Fan, Xin Wei, Gongji Wang, Kehan Li, Hongshu Mu and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chen Shen *Key Laboratory of National Ministry of Health for Forensic Sciences, School of Medicine & Forensics, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID http://orcid.org/0009-0000-8308-5932
Chunfeng Lian *School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an, Shaanxi, China. chunfeng.lian@xjtu.edu.cn.ORCID http://orcid.org/0000-0002-9319-6633
Wanqing ZhangKey Laboratory of National Ministry of Health for Forensic Sciences, School of Medicine & Forensics, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Fan WangKey Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jianhua ZhangShanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai, China.
Shuanliang FanKey Laboratory of National Ministry of Health for Forensic Sciences, School of Medicine & Forensics, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xin WeiKey Laboratory of National Ministry of Health for Forensic Sciences, School of Medicine & Forensics, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Gongji WangKey Laboratory of National Ministry of Health for Forensic Sciences, School of Medicine & Forensics, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Kehan LiKey Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Hongshu MuWeicheng Branch, Xian'yang Public Security Bureau, Xian'yang, Shaanxi, China.
Hao WuKey Laboratory of National Ministry of Health for Forensic Sciences, School of Medicine & Forensics, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xinggong LiangKey Laboratory of National Ministry of Health for Forensic Sciences, School of Medicine & Forensics, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jianhua MaPazhou Lab (Huangpu), Guangzhou, China. jhma@xjtu.edu.cn.
Zhenyuan WangKey Laboratory of National Ministry of Health for Forensic Sciences, School of Medicine & Forensics, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China. wzy218@xjtu.edu.cn.ORCID http://orcid.org/0000-0003-3561-6414

Funding

National Natural Science Foundation of China (National Science Foundation of China) 12326616National Natural Science Foundation of China (National Science Foundation of China) 62101430National Natural Science Foundation of China (National Science Foundation of China) 62101431National Natural Science Foundation of China (National Science Foundation of China) 81730056
6 · The paper itself

Abstract

Forensic pathology plays a vital role in determining the cause and manner of death through macroscopic and microscopic post-mortem examinations. However, the field faces challenges such as variability in outcomes, labor-intensive processes, and a shortage of skilled professionals. This paper introduces SongCi, a visual-language model tailored for forensic pathology. Leveraging advanced prototypical cross-modal self-supervised contrastive learning, SongCi improves the accuracy, efficiency, and generalizability of forensic analyses. Pre-trained and validated on a large multi-center dataset comprising over 16 million high-resolution image patches, 2, 228 vision-language pairs from post-mortem whole slide images, gross key findings, and 471 unique diagnostic outcomes, SongCi demonstrates superior performance over existing multi-modal models and computational pathology foundation models in forensic tasks. It matches experienced forensic pathologists' capabilities, significantly outperforms less experienced practitioners, and offers robust multi-modal explainability.

Indexed as

Forensic PathologyMachine LearningAutopsyHumansImage Processing, Computer-Assisted

Identifiers

PMID40702007
PMCPMC12287307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.