Evidence map›Paper›PMID 40701886›Full record

Observational studyBritish journal of anaesthesia2025

Factors associated with a reduction in the preventive effect of intravenous dexamethasone on rebound pain after axillary brachial plexus block.

Nassim Touil, Athanasia Pavlopoulou, Olivier Barbier, Xavier Libouton, Damien Gruson, Jean-Luc Gala, Patricia Lavand'homme

3 registry-linked trialsAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05763433 unknown statusnot on this map

Evaluation of Intraoperative Dexamethasone Efficacy to Prevent Rebound Pain Phenomenon According to Individual Patient Characteristics

TypeobservationalSponsorCliniques universitaires Saint-Luc- Université Catholique de LouvainRan2023 to 2024Enrolled100ConditionsAdjuvants, Anesthesia, Brachial Plexus AnesthesiaArmsupper extremity bone surgery
NCT07666009 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block: a Single-blinded Randomised Controlled Trial

TypeinterventionalSponsorCentre Hospitalier Universitaire VaudoisRan2026 to 2027Enrolled100ConditionsPost Operative Analgesia, Rebound Pain, Post Operative Pain, AcuteArmsMorphine provided via oral PCA, Morphine provided via oral PCA + morphine administered at a scheduled regimen
NCT07666971 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block: a Single-blinded Randomised Controlled Trial

TypeinterventionalSponsorCentre Hospitalier Universitaire VaudoisRan2026 to 2027Enrolled100ConditionsPost Operative Analgesia, Rebound Pain, Post Operative Pain, AcuteArmsMorphine provided via oral PCA, Morphine provided via oral PCA + morphine administered at a scheduled regimen
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nassim TouilDepartment of Anaesthesiology, Cliniques Universitaires St Luc, Catholic University of Louvain, Brussels, Belgium. Electronic address: nassim.touil@saintluc.uclouvain.be.
Athanasia PavlopoulouDepartment of Anaesthesiology, Cliniques Universitaires St Luc, Catholic University of Louvain, Brussels, Belgium.
Olivier BarbierDepartment of Orthopaedic Surgery, Cliniques Universitaires St Luc, Catholic University of Louvain, Brussels, Belgium.
Xavier LiboutonDepartment of Orthopaedic Surgery, Cliniques Universitaires St Luc, Catholic University of Louvain, Brussels, Belgium.
Damien GrusonDepartment of Laboratory, Cliniques Universitaires St Luc, Catholic University of Louvain, Brussels, Belgium.
Jean-Luc GalaCentre for Applied Molecular Technologies, Catholic University of Louvain, Brussels, Belgium.
Patricia Lavand'hommeDepartment of Anaesthesiology, Cliniques Universitaires St Luc, Catholic University of Louvain, Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRebound pain after regional anaesthesia remains a significant clinical problem. Intravenous dexamethasone is commonly used as an adjuvant to prevent rebound pain although its effectiveness varies among patients. We aimed to identify phenotypic and biological factors influencing glucocorticoid sensitivity contributing to dexamethasone resistance in the prevention of rebound pain.

methodsPatients undergoing ambulatory upper limb surgery with an axillary brachial plexus block were enrolled prospectively to receive dexamethasone (0.1 mg kg

resultsOf the 104 patients included, 36 (34.6%) developed rebound pain. Preoperative nocturnal awakening pain (odds ratio [OR]=3.09, P=0.03), severe anxiety (OR=3.54, P=0.01), high catastrophising score (OR=4.14, P=0.01), and low salivary cortisol levels (<1147 pg ml

conclusionsPreoperative nocturnal pain, severe anxiety, high catastrophising, and low salivary cortisol levels are factors that might reduce the efficacy of dexamethasone in preventing rebound pain. These findings support the development of personalised preventive strategies. CLINICAL

trial registrationNCT05763433.

Indexed as

Brachial Plexus BlockDexamethasoneGlucocorticoidsPostoperative PainAdministration, IntravenousAdultAgedFemaleHumansHydrocortisoneMaleMiddle AgedPain MeasurementProspective StudiesDexamethasoneGlucocorticoidsHydrocortisoneaxillary brachial plexus blockdexamethasoneorthopaedic surgeryperipheral nerve blockrebound pain

Identifiers

PMID40701886
PMCPMC12674082

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.