Evidence map›Paper›PMID 40701784›Full record

ArticleRenal failure2025

Causal relationship between gastroesophageal reflux disease and IgA nephropathy: a Mendelian randomization analysis.

Qiuxia Han, Yingjie Duan, Meiling Jin, Lijie Ma, Xiaolin Zhao, Qinqin Ren, Fei Chen, Xiaonan Ding, Junxia Du, Chenwen Song and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qiuxia HanDepartment of Nephrology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Yingjie DuanDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine, Beijing, China.
Meiling JinDepartment of Nephrology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Lijie MaDepartment of Nephrology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Xiaolin ZhaoDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine, Beijing, China.
Qinqin RenDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine, Beijing, China.
Fei ChenDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine, Beijing, China.
Xiaonan DingDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine, Beijing, China.
Junxia DuDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine, Beijing, China.
Chenwen SongDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine, Beijing, China.
Ke XuDepartment of Medical Affairs, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Hanyu ZhuDepartment of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine, Beijing, China.
Qianmei SunDepartment of Nephrology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIgA nephropathy (IgAN) incidence is higher in gastroesophageal reflux disease (GERD) patients than those without. However, the causal link between them is unclear. This study aims to elucidate the causal relationship between GERD and IgAN through bidirectional Mendelian randomization (MR) analysis.

methodsThe chi-square test was employed to assess whether the incidence of IgAN was associated with GERD. Multivariate logistic regression was used to assess whether GERD is an independent risk factor for IgAN. Univariable and multivariable MR analyses were conducted to estimate the associations between GERD and IgAN. The MR analysis included inverse-variance weighted, MR-Egger, weighted median, simple mode, and weighted mode methods. Additionally, pleiotropy, heterogeneity, and sensitivity analyses were performed.

resultsIn two independent clinical cohorts, GERD patients showed a significantly elevated risk of IgAN. After adjusting for confounding factors such as age, gender, BMI, and hypertension, the results of multivariate logistic regression indicated that GERD is a significant risk factor for IgAN. The MR analysis demonstrated that GERD significantly increased the risk of IgAN (OR = 1.378,

conclusionsThe study suggests that GERD increases the risk of IgAN. However, there is insufficient evidence to support reverse causality between the two diseases.

Indexed as

Gastroesophageal RefluxGlomerulonephritis, IGAAdultFemaleHumansIncidenceLogistic ModelsMaleMendelian Randomization AnalysisMiddle AgedRisk Factorscausal relationshipgastroesophageal reflux diseaseIgA nephropathyMendelian randomizationObservational study

Identifiers

PMID40701784
PMCPMC12288176

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