Evidence map›Paper›PMID 40701643›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2025

Treating connective tissue disease-associated interstitial lung disease - think outside the box: a perspective.

Yet H Khor, Catharina C Moor, Wolfgang Merkt, Katharina Buschulte, Boyang Zheng, Veronika Müller, Michael Kreuter

Abstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yet H KhorRespiratory Research@Alfred, Central Clinical School, Monash University, Melbourne, Australia yet.khor@monash.edu.ORCID https://orcid.org/0000-0002-5434-9342
Catharina C MoorDepartment of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-5295-2877
Wolfgang MerktDepartment of Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine University, Düsseldorf, Germany.
Katharina BuschulteCenter for Interstitial and Rare Lung Diseases, Pneumology and Respiratory Critical Care Medicine, Thoraxklinik, University of Heidelberg, German Center for Lung Research (DZL), Heidelberg, Germany.
Boyang ZhengDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Veronika MüllerDepartment of Pulmonology, Semmelweis University, Budapest, Hungary.
Michael KreuterMainz Center for Pulmonary Medicine, Department of Pneumology, Mainz University Medical Center and Department of Pulmonary, Critical Care and Sleep Medicine, Marienhaus Clinic Mainz, Mainz, Germany yet.khor@monash.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Connective tissue disease-associated interstitial lung disease is one of the most common subtypes of interstitial lung disease, which is a leading cause of morbidity and mortality in patients with these systemic autoimmune rheumatic diseases. A spectrum of disease trajectories exists within individual and across different connective tissue diseases. In individuals with connective tissue diseases who are at risk or at the early asymptomatic stage with interstitial lung changes, we have potential windows of opportunity for interventions to prevent the development of or progression to interstitial lung disease. In this perspective, we use systemic sclerosis and rheumatoid arthritis as sample cases to discuss emerging knowledge on disease pathogenesis, as well as to apply the preventative medicine concept for pharmacotherapeutic approaches at different disease stages of connective tissue disease-associated interstitial lung disease.

Indexed as

Antirheumatic AgentsArthritis, RheumatoidConnective Tissue DiseasesLungLung Diseases, InterstitialScleroderma, SystemicDisease ProgressionHumansRisk FactorsTreatment OutcomeAntirheumatic Agents

Identifiers

PMID40701643
PMCPMC12284716

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.