Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Abeselom FantaDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States.ORCID 0000-0003-0592-861X
Atinuke Dosunmu-OgunbiDepartment of Medicine, Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Alexander RueschDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States.
Jude JonassaintDepartment of Medicine, Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Joel D K DisuDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States.ORCID 0009-0003-1795-7861
Julia Z XuDepartment of Medicine, Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Theodore HuppertDepartment of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Jana M KainerstorferDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-9481-8377
Enrico M NovelliDepartment of Medicine, Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Sossena WoodDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States.ORCID 0000-0003-3079-1096
Funding
University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Neurovascular Determinants of Cognitive Function in Adults with Sickle Cell DiseaseR01HL127107 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NOVELLI, ENRICO M · 2016 to 2020
$3.6M
Carnegie Mellon University (CMU) Presidential Postdoctoral FellowshipHHS | National Institutes of Health (NIH) R01- HL127107HHS | National Institutes of Health (NIH) UL1TR001857NCATS NIH HHS UL1 TR001857NHLBI NIH HHS R01 HL127107
6 · The paper itself
Abstract
Cerebral small vessel disease is a neurological complication of sickle cell disease (SCD) associated with cerebral hypoperfusion and cognitive dysfunction. Early and prompt detection is important for prevention and treatment, preferably with a noninvasive, inexpensive point-of-care test. Impaired cerebral autoregulation (CA) is a marker of cerebral small vessel disease, so we evaluated whether imaging hemodynamic changes in the microvasculature can assess abnormal CA in patients with SCD. We instructed patients (
Indexed as
Anemia, Sickle CellBrainCerebrovascular CirculationHomeostasisAdultCerebral Small Vessel DiseasesFemaleHemodynamicsHemoglobinsHumansMaleOxyhemoglobinsSpectroscopy, Near-InfraredYoung AdultdeoxyhemoglobinHemoglobinsOxyhemoglobinscerebral autoregulationcerebral blood transit timescerebral small vessel diseasenear-infrared spectroscopysickle cell disease
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Assessment of cerebral autoregulation and cerebral perfusion in patients with sickle cell disease using frequency-domain near-infrared spectroscopy. · full record | OpenQuestion