ArticleEuropean journal of dentistry2026
Diagnostic Potential of aMMP-8 PoCT in Oral Fluids: Insights from Periodontitis and Metabolic Syndrome Interplay.
Article in European journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Clinical Status and Salivary aMMP-8 Evaluation of 0.12% Chlorhexidine Versus MicroRepairDentistry journal · 2026Article
- Longitudinal biomarker profiles during experimental gingivitis: a predictor of susceptibility.Clinical oral investigations · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study evaluated the expression of active-matrix metalloproteinase-8 (aMMP-8) in saliva, oral rinse, and gingival crevicular fluid (GCF) of periodontitis patients with and without metabolic syndrome (MetS) and assessed correlations between aMMP-8 levels and both periodontal and metabolic parameters. Materials and Methods: One hundred and twenty participants aged 25 to 55 years were classified into three groups: MetS with periodontitis (MetS-PD, Statistical Analysis: The median age of the participants was 49.5 ± 8.94 in MetS-PD, 47.5 ± 5.6 in SH-PD, and 42.5 ± 11.14 in SH-PH. Systemic parameters (waist circumference, blood pressure, lipid profile, and glycemic indices) and periodontal parameters (bleeding on probing, plaque score, probing depth, and clinical attachment loss) were assessed. aMMP-8 was evaluated qualitatively using point-of-care testing (PoCT) and quantitatively via ELISA in oral rinse, saliva, and GCF. Results: The PoCT was positive in 90% of MetS-PD and 85% of SH-PD participants, while all SH-PH participants tested negative ( Conclusion: The aMMP-8 PoCT effectively distinguished periodontally diseased individuals from healthy controls. Elevated aMMP-8 levels (>20 ng/mL) in oral fluids, especially saliva and oral rinse, were significantly associated with both periodontal and systemic risk factors, supporting the potential of aMMP-8 as a noninvasive biomarker for periodontitis and metabolic disorders.
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Registered trials
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