Evidence map›Paper›PMID 40701113›Full record

ArticlePsychiatry research. Neuroimaging2025

Morphometric brain MRI findings in hair-pulling and skin-picking disorders in youth.

Joseph O'Neill, Tara S Peris, Emily J Ricketts, Jon E Grant, Christine Lochner, Dan J Stein, Darin D Dougherty, Douglas W Woods, Matthew J Kempton, Nancy J Keuthen and 1 more

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Article in Psychiatry research. Neuroimaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Joseph O'NeillDivision of Child & Adolescent Psychiatry, UCLA Semel Institute For Neuroscience, Los Angeles, CA, USA; UCLA Brain Research Institute, Los Angeles, CA, USA. Electronic address: joneill@mednet.ucla.edu.
Tara S PerisDivision of Child & Adolescent Psychiatry, UCLA Semel Institute For Neuroscience, Los Angeles, CA, USA.
Emily J RickettsDivision of Child & Adolescent Psychiatry, UCLA Semel Institute For Neuroscience, Los Angeles, CA, USA.
Jon E GrantDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Christine LochnerSA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
Dan J SteinSA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Darin D DoughertyDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
Douglas W WoodsDivision of Academic Addairs, Loyola University Chicago, Chicago, IL, USA.
Matthew J KemptonDepartment of Psychosis Studies, Psychology & Neuroscience, King's College London, UK.
Nancy J KeuthenDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
John C PiacentiniDivision of Child & Adolescent Psychiatry, UCLA Semel Institute For Neuroscience, Los Angeles, CA, USA.

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
NCATS NIH HHS UL1 TR000430
6 · The paper itself

Abstract

Pediatric hair-pulling disorder (HPD) and skin-picking disorder (SPD) are treatment-resistant conditions understudied with neuroimaging. We report cross-sectional morphometric MRI results from the adolescent-early adult subsample of the Body-Focused Precision Medicine Initiative (BPMI), a major HPD-SPD MRI database. Participants aged 11-21 years comprised 30 with HPD, 13 with SPD, 16 with both HPD and SPD, and 29 typically developing (TD). Whole-brain MRI was parcellated into cortical and subcortical regions with FreeSurfer. Volume and (for cortex) thickness and surface area of each region were analyzed for effects of HPD and SPD, controlling for psychotropic medication, age, total intracranial volume, and scanning site. Morphometry of four regions most reflected diagnosis and severity of HPD: 1) left inferior frontal cortex (larger and thicker for more severe HPD); 2) corpus callosum (larger for more severe HPD); 3) lingual gyrus (smaller right cortical surface area and white-matter volume); and 4) fusiform gyrus (smaller right cortical and white-matter volumes for more severe HPD). For SPD, there were three regions: 1) parahippocampal gyrus (larger left white matter volume and larger bilateral cortical volume and surface area for more severe SPD); 2) fusiform cortex (thicker left cortex for more severe skin-picking urgency); and 3) entorhinal cortex (thicker right cortex for more severe urgency). Variations in regional morphometry may result from or predispose to HPD and SPD. Left inferior frontal and callosal findings suggest lateralized dysfunction in HPD similar to language disorders; in SPD parahippocampal findings may indicate dysfunction in emotion regulation and/or contextual association.

Indexed as

BrainSelf-Injurious BehaviorTrichotillomaniaAdolescentChildCorpus CallosumCross-Sectional StudiesExcoriation DisorderFemaleHumansMagnetic Resonance ImagingMaleWhite MatterYoung AdultBrain morphologyCorpus callosumExcoriationInferior frontal cortexParahippocampal cortexTrichotillomania

Identifiers

PMID40701113
PMCPMC13506253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.