Evidence map›Paper›PMID 40700960›Full record

ArticleThe Journal of surgical research2025

Impaired Diabetic Myocutaneous Wound Revascularization Is Associated With Reduced Transdermal H

Joseph Giacolone, Deepali Kulkarni, Carolyn Pace, Benjamin Matheson, Nancy Kanagy, Ross M Clark

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joseph GiacoloneDepartment of Surgery, University of New Mexico, Albuquerque, New Mexico.
Deepali KulkarniDepartment of Surgery, University of New Mexico, Albuquerque, New Mexico.
Carolyn PaceDepartment of Surgery, University of New Mexico, Albuquerque, New Mexico.
Benjamin MathesonDepartment of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico.
Nancy KanagyDepartment of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico.
Ross M ClarkDepartment of Surgery, University of New Mexico, Albuquerque, New Mexico; Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico. Electronic address: rmclark@salud.unm.edu.

Funding

University of New Mexico Clinical and Translational Science CenterKL2TR001448 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CANNON, JUDY LIN · 2015 to 2024
$3.5M
Transdermal H2S Sensing Device for Monitoring Peripheral Artery DiseaseR44HL121871 · NHLBI · EXHALIX, LLC · PI KANAGY, NANCY L, SHEKARRIZ, REZA · 2018 to 2019
$1.5M
NCATS NIH HHS KL2 TR001448NHLBI NIH HHS R44 HL121871
6 · The paper itself

Abstract

introductionAs the prevalence of diabetes mellitus continues to rise, morbidity associated with nonhealing diabetic wounds is becoming more common. Hydrogen sulfide (H MATERIALS AND

methodsSprague Dawley and Zucker diabetic fatty (ZDF) rats underwent creation of full-thickness ischemic myocutaneous flap wounds. Revascularization was followed for 14 days by serial laser speckle contrast imaging and transdermal H

resultsZDF rats were observed to have impaired skin perfusion at baseline and during flap engraftment [64 perfusion units (PU) versus 184 PU, P < 0.01], which mirrored deficits in H

conclusionsImpairments in transdermal H

Indexed as

Diabetes Mellitus, ExperimentalHydrogen SulfideIschemiaMyocutaneous FlapNeovascularization, PhysiologicSkinWound HealingAnimalsMaleRatsRats, Sprague-DawleyRats, ZuckerVascular Endothelial Growth Factor AHydrogen SulfideVascular Endothelial Growth Factor AAngiogenesisHydrogen sulfideTherapeuticsTissue ischemiaWound healing

Identifiers

PMID40700960
PMCPMC12313196

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.