Evidence map›Paper›PMID 40700713›Full record

ReviewAmerican journal of respiratory cell and molecular biology2026

Multi-Omic and Single-Cell Approaches for Elucidating Cell Biology and Pathobiology of Lung Disease.

Aartik Sarma, Xin Sun, Jennifer Sucre, Jason Hong, Lejla Medzikovic, Claudia V Jakubzick, Xin Li, Rachel L Zemans, Benjamin D Singer

Abstract readReview
In one paragraph

Review in American journal of respiratory cell and molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Respiratory immunology: an ancient yet emerging interdisciplinary field.Chinese medical journal pulmonary and critical care medicine · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aartik SarmaDepartment of Medicine, University of California, San Francisco, San Francisco, California.
Xin SunDepartment of Pediatrics, University of California, San Diego, San Diego, California.
Jennifer SucreDepartment of Pediatrics, Vanderbilt University, Nashville, Tennessee.
Jason HongDepartment of Medicine and.
Lejla MedzikovicDepartment of Anesthesiology and Perioperative Medicine, University of California, Los Angeles, Los Angeles, California.
Claudia V JakubzickDepartment of Microbiology and Immunology, Dartmouth Geisel School of Medicine, Hanover, New Hampshire.ORCID 0000-0002-3731-0198
Xin LiDepartment of Microbiology and Immunology, Dartmouth Geisel School of Medicine, Hanover, New Hampshire.ORCID 0000-0002-2050-2628
Rachel L ZemansDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan; and.
Benjamin D SingerDepartment of Medicine and.ORCID 0000-0001-5775-8427

Funding

Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RICHARD G WUNDERINK · 2018 to 2026
$24.7M
The Cell Phenotyping and Mouse CoreP01HL154998 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE · 2021 to 2026
$18.9M
Human and mouse transcriptome profiling identifies cross-species homology of mononuclear phagocytesR35HL155458 · NHLBI · DARTMOUTH COLLEGE · PI Claudia V Jakubzick · 2021 to 2026
$5.9M
Mechanisms of Alveolar Homeostasis, Injury, Regeneration, and FibrosisR35HL160770 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Rachel Lynne Zemans · 2022 to 2026
$4.3M
Mechanisms of regulatory T cell-mediated recovery from severe viral pneumoniaR01HL149883 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2020 to 2026
$4.1M
Evolution and resolution of ARDS molecular phenotypesK23HL163491 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aartik Sarma · 2023 to 2026
$750k
Epigenetic modifiers of regulatory T cell function following viral pneumoniaR01HL153122 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SINGER, BENJAMIN DAVID · 2021 to 2021
$63k
NHLBI NIH HHS K23HL163491NHLBI NIH HHS P01 HL154998NHLBI NIH HHS R01 HL149883NHLBI NIH HHS R01 HL153122NHLBI NIH HHS R35 HL155458NHLBI NIH HHS R35 HL160770NIAID NIH HHS U19 AI135964
6 · The paper itself

Abstract

In this Perspective, we review the major themes from a Basic Science Core session at the American Thoracic Society 2024 International Conference: multi-omic and single-cell approaches for elucidating cellular biology and pathobiology of lung disease, with a focus on novel biology identified in human lungs. Recent advances have enabled researchers to study nucleic acids, proteins, and metabolites at single-cell resolution in the lung. These tools can be integrated with complementary methods to lead to new discoveries about lung function and develop treatments for respiratory diseases. We discuss the role of multicenter consortia in developing lung cell atlases and highlight the role of single-cell methods in identifying new respiratory cell types. We then review advances in several respiratory diseases that demonstrate the use of these tools to study lung development, injury, and repair. Finally, we consider future directions for the field, including efforts to harmonize cell types across studies and to develop more robust analytical pipelines.

Indexed as

LungLung DiseasesSingle-Cell AnalysisAnimalsHumansMultiomicsenodthelial cellsepithelial cellsgenomicsstromal cellstranscriptomics

Identifiers

PMID40700713
PMCPMC12313468

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.