Evidence map›Paper›PMID 40700584›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025

Physical activity mediates age differences in cognition among Tsimane forager-horticulturalists.

Phoebe Imms, Nikhil N Chaudhari, Daniel Cummings, Daniel Eid Rodriguez, Giuseppe Barisano, Paul L Hooper, M Katherine Sayre, Edmond Seabright, Randall C Thompson, M Linda Sutherland and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Phoebe ImmsEthel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States.ORCID 0000-0002-7205-4177
Nikhil N ChaudhariEthel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States.
Daniel CummingsDepartment of Anthropology, University of New Mexico, Albuquerque, New Mexico, United States.
Daniel Eid RodriguezInstitute of Biomedical Research, Universidad Mayor de San Simon, Cochabamba, Bolivia.
Giuseppe BarisanoDepartment of Neurosurgery, Stanford University, Stanford, California, United States.
Paul L HooperDepartment of Anthropology, University of New Mexico, Albuquerque, New Mexico, United States.
M Katherine SayreDepartment of Anthropology, University of California, Santa Barbara, California, United States.
Edmond SeabrightDepartment of Anthropology, University of New Mexico, Albuquerque, New Mexico, United States.
Randall C ThompsonSaint Luke's Mid America Heart Institute, University of Missouri, Kansas City, Missouri, United States.
M Linda SutherlandDepartment of Radiology, MemorialCare Health Systems, Fountain Valley, California, United States.
James D SutherlandDepartment of Radiology, MemorialCare Health Systems, Fountain Valley, California, United States.
Benjamin C TrumbleCenter for Evolution & Medicine, School of Human Evolution and Social Change, Arizona State University, Tempe, Arizona, United States.ORCID 0000-0003-3201-0628
Michael GurvenDepartment of Anthropology, University of California, Santa Barbara, California, United States.ORCID 0000-0002-5661-527X
Jonathan StieglitzInstitute for Advanced Study in Toulouse, Toulouse, France.
Caleb E FinchEthel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States.ORCID 0000-0002-7617-3958
Hillard S KaplanEconomic Science Institute, Argyros School of Business and Economics, Chapman University, Orange, California, United States.
Wendy J MackDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
Margaret GatzCenter for Economic and Social Research, Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California, United States.ORCID 0000-0002-1071-9970
Andrei IrimiaEthel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States.ORCID 0000-0002-9254-9388

Funding

Testing Hypothesized Pathways Linking Infection, Physical Activity, Apoe Genotype, And Biological Sex To Low Dementia Prevalence And Reduced Brain Atrophy In Two Native American PopulationsR01AG054442 · NIA · CHAPMAN UNIVERSITY · PI CALEB E FINCH, Margaret Gatz · 2022 to 2026
$15.2M
Brain atrophy, cognitive impairment and Alzheimer's in low CVD-risk populationRF1AG054442 · NIA · UNIVERSITY OF NEW MEXICO · PI FINCH, CALEB E, GURVEN, MICHAEL DOUGLAS · 2017 to 2020
$8.8M
Neurovascular calcification, Alzheimer’s disease and related dementias in two Native South American populationsRF1AG082201 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI IRIMIA, ANDREI · 2023 to 2023
$2.5M
National Science Foundation 1748282NIA NIH HHS R01 AG054442NIA NIH HHS RF1 AG054442NIA NIH HHS RF1 AG082201NIH HHS R01 AG 054442NIH HHS RF1 AG 054442NIH HHS RF1 AG 082201
6 · The paper itself

Abstract

backgroundThe Tsimane and Moseten of the Bolivian Amazon are highly physically active and exhibit low rates of cognitive impairment and brain atrophy.

methodsWe use structural equation modelling to examine how their physical activity levels mediate the relationship between (1) age and cognition, and (2) age and cognition via brain volume (BV).

resultsTsimane males (n = 305, mean ± SD age = 59.94 ± 9.68) and Tsimane females (n = 265, mean ± SD age = 59.28 ± 9.79) exhibit significantly higher levels of physical activity than Moseten males (n = 106, mean ± SD age = 58.15 ± 9.93) and Moseten females (n = 96, mean ± SD age = 56.63 ± 9.69). Physical activity significantly mediates the relationship between age and cognition in Tsimane males (indirect effect estimate ݼ = -0.01, P < .01) and Tsimane females (indirect effect estimate ݼ = -0.04, P = .01), but not in Moseten males or females.

conclusionsAmong Tsimane males, who are more physically active than Tsimane females, the association between age and cognition via BV is significantly mediated by physical activity. Among Tsimane females, mediation occurs directly via physical activity, bypassing BV. These results suggest that mechanisms of cognitive differences across ages differ by sex and population. Studying the relationship between brain atrophy and lifestyle in nonindustrialized populations elucidates biological and environmental correlates of brain health.

Indexed as

AgingBrainCognitionExerciseIndians, South AmericanAgedAge FactorsBoliviaFemaleHumansMagnetic Resonance ImagingMaleMiddle Agedbrain atrophycognitive declineexercisenovel aging populationTsimane and Moseten

Identifiers

PMID40700584
PMCPMC12365640

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.