Evidence map›Paper›PMID 40700577›Full record

ArticleBlood2025

CD99 promotes self-renewal in hematopoietic stem cells and leukemia stem cells by regulating protein synthesis.

Yuanyuan Ji, Yi Huang, Toby Thomas, Eda Gozel Kapti, Reiko Tachibana, Jacob Lark, Iryna Berezniuk, Liang Guo, Mohamed A E Ali, Karin Mims and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Yuanyuan JiDivision of Hematology/Oncology, Department of Internal Medicine, Children's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, TX.
Yi HuangDivision of Hematology/Oncology, Department of Internal Medicine, Children's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, TX.
Toby ThomasDivision of Hematology/Oncology, Department of Internal Medicine, Children's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, TX.ORCID 0009-0004-1707-4951
Eda Gozel KaptiDivision of Hematology/Oncology, Department of Internal Medicine, Children's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, TX.
Reiko TachibanaDivision of Hematology/Oncology, Department of Internal Medicine, Children's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, TX.
Jacob LarkDivision of Hematology/Oncology, Department of Internal Medicine, Children's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, TX.
Iryna BerezniukDepartment of Pathology, New York University Grossman School of Medicine, New York, NY.
Liang GuoDepartment of Pathology, New York University Grossman School of Medicine, New York, NY.
Mohamed A E AliDepartment of Pathology, New York University Grossman School of Medicine, New York, NY.ORCID 0000-0003-2352-2760
Karin MimsDivision of Hematology/Oncology, Department of Internal Medicine, Children's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, TX.
Benjamin KrogerDivision of Hematology/Oncology, Department of Internal Medicine, Children's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, TX.ORCID 0000-0001-5675-9102
Wenhuo HuIndependent Contractor, Bethany, CT.
Christopher Y ParkDepartment of Pathology, New York University Grossman School of Medicine, New York, NY.ORCID 0000-0003-2018-3476
Stephen S ChungDivision of Hematology/Oncology, Department of Internal Medicine, Children's Medical Center Research Institute, The University of Texas Southwestern Medical Center, Dallas, TX.

Funding

Translational Control of Leukemia Stem Cells - Resubmission - 1R01CA245502 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PARK, CHRISTOPHER Y · 2020 to 2024
$2.2M
NCI NIH HHS R01 CA245502
6 · The paper itself

Abstract

abstractBlood production is sustained by hematopoietic stem cells (HSCs), which are typically the only blood cells capable of long-term self-renewal. HSCs exhibit and depend on low levels of protein synthesis to self-renew. However, the mechanisms by which HSCs regulate protein synthesis to maintain their self-renewal capacity during proliferative stress and leukemogenesis remain unknown. Here we show CD99, a protein upregulated in leukemia stem cells (LSCs) in acute myeloid leukemia (AML), is required for the self-renewal of proliferating HSCs and LSCs. We found that loss of CD99 in HSCs and LSCs leads to increased protein synthesis, and that their self-renewal capacity can be restored by translation inhibition. These data demonstrate a functional role for CD99 in constraining protein synthesis, which may promote the clonal expansion of HSCs and LSCs that leads to AML. Furthermore, these studies demonstrate that similar to HSCs, LSCs depend on maintenance of tightly regulated protein synthesis rates.

Indexed as

12E7 AntigenCell Self RenewalHematopoietic Stem CellsLeukemia, Myeloid, AcuteNeoplastic Stem CellsProtein BiosynthesisAnimalsCell ProliferationHumansMice12E7 AntigenCD99 protein, human

Identifiers

PMID40700577
PMCPMC12824702

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.