Evidence map›Paper›PMID 40700517›Full record

ArticleScience translational medicine2025

Protective envelope dimer epitope-like antibodies are elicited against dengue virus in children after infection and vaccination.

Patrick I Mpingabo, Michelle Ylade, Rosemary A Aogo, Maria Vinna Crisostomo, Devina J Thiono, Jedas Veronica Daag, Kristal-An Agrupis, Ana Coello Escoto, Guillermo L Raimundi-Rodriguez, Camila D Odio and 5 more

Abstract read
In one paragraph

Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Patrick I MpingaboViral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA.ORCID 0000-0001-8970-460X
Michelle YladeInstitute of Child Health and Human Development, National Institutes of Health, University of the Philippines-Manila, Ermita, 1000 Manila, Philippines.ORCID 0000-0002-2653-4460
Rosemary A AogoViral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA.ORCID 0000-0003-4588-4914
Maria Vinna CrisostomoInstitute of Child Health and Human Development, National Institutes of Health, University of the Philippines-Manila, Ermita, 1000 Manila, Philippines.ORCID 0000-0002-4702-4929
Devina J ThionoDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599-7290, USA.ORCID 0000-0002-8330-0396
Jedas Veronica DaagInstitute of Child Health and Human Development, National Institutes of Health, University of the Philippines-Manila, Ermita, 1000 Manila, Philippines.
Kristal-An AgrupisInstitute of Child Health and Human Development, National Institutes of Health, University of the Philippines-Manila, Ermita, 1000 Manila, Philippines.ORCID 0000-0003-2917-2589
Ana Coello EscotoViral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA.ORCID 0000-0002-9634-5091
Guillermo L Raimundi-RodriguezViral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA.ORCID 0000-0002-8456-7412
Camila D OdioViral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA.
Maria Abad FernandezDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599-7290, USA.
Laura WhiteDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599-7290, USA.
Aravinda M de SilvaDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599-7290, USA.ORCID 0000-0003-3317-5950
Jacqueline DeenInstitute of Child Health and Human Development, National Institutes of Health, University of the Philippines-Manila, Ermita, 1000 Manila, Philippines.ORCID 0000-0001-8875-5026
Leah C KatzelnickViral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA.ORCID 0000-0003-1033-6758

Funding

Project 5: mAb Development Flaviviruses and AlphavirusesU19AI181960 · NIAID · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S, KUHN, RICHARD J. · 2024 to 2024
$46.7M
T Cell Responses Following DENV Natural Infections and Live-Attenuated Dengue Virus VaccinationP01AI106695 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Eva Harris · 2015 to 2026
$34.1M
Immunology, virology, and epidemiology of flaviviruses and other emerging virusesZIAAI001346 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KATZELNICK, LEAH · 2021 to 2025
$7.1M
Intramural NIH HHS ZIA AI001346NIAID NIH HHS P01 AI106695NIAID NIH HHS U19 AI181960
6 · The paper itself

Abstract

Cross-reactive antibodies to epitopes that span envelope proteins on the virion surface are hypothesized to protect against dengue virus (DENV) infection and disease. Here, we measured antibodies targeting a quaternary epitope called the envelope dimer epitope (EDE) as well as neutralizing and binding antibodies and evaluated their association with DENV infection, vaccine response, and disease outcome in dengue-vaccinated (

Indexed as

Antibodies, ViralDengueDengue VaccinesDengue VirusEpitopesVaccinationViral Envelope ProteinsAntibodies, NeutralizingChildChild, PreschoolFemaleHumansMalePhilippinesAntibodies, NeutralizingAntibodies, ViralDengue VaccinesEpitopesViral Envelope Proteins

Identifiers

PMID40700517
PMCPMC12351287

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.