Evidence map›Paper›PMID 40700505›Full record

ArticleScience advances2025

M6A-dependent RNA condensation underlies FUS autoregulation and can be harnessed for ALS therapy development.

Wan-Ping Huang, Vedanth Kumar, Karen Yap, Haiyan An, Sabin J John, Rachel E Hodgson, Anna Sanchez Avila, Emily Day, Brittany C S Ellis, Tek Hong Chung and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Wan-Ping HuangSheffield Institute for Translational Neuroscience (SITraN) and Neuroscience Institute, University of Sheffield, Sheffield, UK.ORCID 0009-0003-1656-5508
Vedanth KumarSheffield Institute for Translational Neuroscience (SITraN) and Neuroscience Institute, University of Sheffield, Sheffield, UK.ORCID 0009-0000-7310-9769
Karen YapCentre for Developmental Biology, King's College London, London, UK.
Haiyan AnMedical School, Swansea University, Swansea, UK.ORCID 0000-0002-2545-3757
Sabin J JohnSheffield Institute for Translational Neuroscience (SITraN) and Neuroscience Institute, University of Sheffield, Sheffield, UK.ORCID 0009-0000-7628-1484
Rachel E HodgsonSheffield Institute for Translational Neuroscience (SITraN) and Neuroscience Institute, University of Sheffield, Sheffield, UK.ORCID 0009-0000-5427-2560
Anna Sanchez AvilaSheffield Institute for Translational Neuroscience (SITraN) and Neuroscience Institute, University of Sheffield, Sheffield, UK.
Emily DaySheffield Institute for Translational Neuroscience (SITraN) and Neuroscience Institute, University of Sheffield, Sheffield, UK.ORCID 0009-0006-3030-084X
Brittany C S EllisSheffield Institute for Translational Neuroscience (SITraN) and Neuroscience Institute, University of Sheffield, Sheffield, UK.
Tek Hong ChungCentre for Developmental Biology, King's College London, London, UK.ORCID 0000-0002-9572-8023
Jenny LordSheffield Institute for Translational Neuroscience (SITraN) and Neuroscience Institute, University of Sheffield, Sheffield, UK.ORCID 0000-0002-0539-9343
Michaela Müller-McNicollInstitute of Molecular Biosciences, Goethe University, Frankfurt am Main, Germany.ORCID 0000-0002-7174-8310
Eugene V MakeyevCentre for Developmental Biology, King's College London, London, UK.ORCID 0000-0001-6034-6896
Tatyana A ShelkovnikovaSheffield Institute for Translational Neuroscience (SITraN) and Neuroscience Institute, University of Sheffield, Sheffield, UK.ORCID 0000-0003-1367-5309

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the

Indexed as

AdenosineAmyotrophic Lateral SclerosisRNARNA-Binding Protein FUSHumansIntronsMethylationMutationNerve Tissue ProteinsRNA, MessengerRNA SplicingRNA Splicing FactorsAdenosineFUS protein, humanNerve Tissue ProteinsN-methyladenosineRNARNA-Binding Protein FUSRNA, MessengerRNA Splicing FactorsYTHDC1 protein, human

Identifiers

PMID40700505
PMCPMC12285722

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.