Evidence map›Paper›PMID 40700493›Full record

ArticleScience advances2025

Genetic history of Scythia.

Tatiana V Andreeva, Anna D Soshkina, Fedor E Gusev, Alexandra B Malyarchuk, Gleb S Dotsenko, Natalia A Dudko, Maria Yu Plotnikova, Svetlana S Kunizheva, Andrey D Manakhov, Tatiana V Ustkachkintseva and 11 more

Erratum issuedAbstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Tatiana V AndreevaCenter for Genetics and Life Science, Sirius University of Science and Technology, Sochi 354340, Russia.ORCID 0000-0001-7625-0063
Anna D SoshkinaLaboratory of Evolutionary Genomics, Department of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia.
Fedor E GusevCenter for Genetics and Life Science, Sirius University of Science and Technology, Sochi 354340, Russia.
Alexandra B MalyarchukFaculty of Biology, Center for Genetics and Genetic Technologies, Lomonosov Moscow State University, Moscow 119192, Russia.
Gleb S DotsenkoLaboratory of Evolutionary Genomics, Department of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia.
Natalia A DudkoCenter for Genetics and Life Science, Sirius University of Science and Technology, Sochi 354340, Russia.ORCID 0000-0002-7272-4943
Maria Yu PlotnikovaCenter for Genetics and Life Science, Sirius University of Science and Technology, Sochi 354340, Russia.ORCID 0000-0002-4578-7471
Svetlana S KunizhevaCenter for Genetics and Life Science, Sirius University of Science and Technology, Sochi 354340, Russia.
Andrey D ManakhovCenter for Genetics and Life Science, Sirius University of Science and Technology, Sochi 354340, Russia.ORCID 0000-0002-5163-8747
Tatiana V UstkachkintsevaLaboratory of Evolutionary Genomics, Department of Genomics and Human Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia.ORCID 0009-0007-0925-5906
Maria S ProtasovaCenter for Genetics and Life Science, Sirius University of Science and Technology, Sochi 354340, Russia.ORCID 0000-0002-2422-1540
Semyon A VolodinInstitute of Archaeology, Russian Academy of Sciences, Moscow 117292, Russia.ORCID 0000-0003-3681-3241
Alexandra P BuzhilovaInstitute of Archaeology, Russian Academy of Sciences, Moscow 117292, Russia.ORCID 0000-0001-6398-2177
Yuriy D RazuvaevVoronezh State Pedagogical University, Voronezh 394018, Russia.
Natalia Ya BerezinaResearch Institute and Museum of Anthropology, Lomonosov Moscow State University, Moscow 125009, Russia.ORCID 0000-0001-5704-9153
Yakov B BerezinResearch Institute and Museum of Anthropology, Lomonosov Moscow State University, Moscow 125009, Russia.ORCID 0000-0003-0417-4668
Anatoly R KantorovichDepartment of Archaeology, Faculty of History, Lomonosov Moscow State University, Moscow 119234, Russia.ORCID 0000-0001-8392-9445
Vladimir E MaslovInstitute of Archaeology, Russian Academy of Sciences, Moscow 117292, Russia.ORCID 0000-0002-4910-8317
Dmitry G BarinovAutonomous non-profit organization "Scientific Research Center for the Preservation of Cultural Heritage", Saratov 410056, Russia.ORCID 0009-0000-0890-8097
Maria V DobrovolskayaInstitute of Archaeology, Russian Academy of Sciences, Moscow 117292, Russia.ORCID 0000-0001-9695-4199
Evgeny I RogaevCenter for Genetics and Life Science, Sirius University of Science and Technology, Sochi 354340, Russia.ORCID 0000-0002-0351-8783

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Great Scythia was the ancient Greek name for the area stretching from the northern Black Sea coast to the Middle Don. Using high-quality genomic data generated from 131 ancient individuals from Great Scythia and neighboring regions of the Bronze Age and the Iron Age, we established the genetic structure of the Scythians, revealing their diverse origin with major European Bronze Age ancestral components, and genetic traces of migration and invasions. We uncovered relationships between Scythians, including elite Scythians. Substantial endogamy in the Scythian clan was found. We examined Scythians' phenotypes and medical-genetic background and found a harmful gene mutation causing fructose intolerance. This ancient "Scythian" mutation has spread throughout West Eurasia and has become the most prevalent genetic cause of fructose intolerance in contemporary European populations.

Indexed as

Genetics, PopulationEuropeFructose IntoleranceHumansMutationPhenotype

Identifiers

PMID40700493
PMCPMC12285711

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.